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Ubiquitin Specific Peptidase 39 (USP39)

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SAD1; CGI-21; SNRNP65; SnRNP Assembly Defective 1 Homolog; Inactive ubiquitin-specific peptidase 39; Small Nuclear Ribonucleoprotein 65kDa(U4/U6.U5)

Ubiquitin Specific Peptidase 39 (USP39)
CCC N592
HGNC 20071
MGI 107622
PubMed 21249182
RGD 1308103
UniProt Q53GS9
The deduced 565-amino acid protein has a calculated molecular mass of 65.4 kD. The N-terminal domain is rich in arginine, serine, and glutamic acid and resembles the RS domain of SR-related proteins, such as SNRP70 and RY1. USP39 also contains a central zinc finger and 2 ubiquitin C-terminal hydrolase (UCH) domains. USP39 shares 65% amino acid similarity with yeast Sad1. Increasing amounts of anti-USP39 antibody resulted in accumulation of unspliced pre-mRNAs, suggesting that USP39 has a role in pre-mRNA splicing. Immunodepletion of USP39 strongly inhibited splicing. Immunoprecipitation at increasing salt concentrations demonstrated that USP39 was not required for stability of the U4/U6.U5 tri-snRNP but was essential for recruitment of the tri-snRNP to the prespliceosome.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Specific Peptidase 39 (USP39) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Specific Peptidase 39 (USP39) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Specific Peptidase 39 (USP39) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Specific Peptidase 39 (USP39) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Specific Peptidase 39 (USP39) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Specific Peptidase 39 (USP39) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Specific Peptidase 39 (USP39) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Specific Peptidase 39 (USP39) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Specific Peptidase 39 (USP39) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Specific Peptidase 39 (USP39) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Specific Peptidase 39 (USP39) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Specific Peptidase 39 (USP39) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Specific Peptidase 39 (USP39) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Specific Peptidase 39 (USP39) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Specific Peptidase 39 (USP39) ELISA Kit Customized Service Offer
  1. "The 65 and 110 kDa SR-related proteins of the U4/U6*U5 tri-snRNP are essential for the assembly of mature spliceosomes."EMBO J. 20:2553-2563(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP."RNA 12:1418-1430(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Usp39 is essential for mitotic spindle checkpoint integrity and controls mRNA-levels of aurora B."Cell Cycle 7:2710-2719(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]