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HAUS Augmin Like Complex Subunit 4 (HAUS4)

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C14orf94

HAUS Augmin Like Complex Subunit 4 (HAUS4)
CCC N582
HGNC 20163
MGI 1261794
RGD 1305288
UniProt Q9H6D7
HAUS4 is 1 of 8 subunits of the 390-kD human augmin complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly.
HAUS4 is a critical component of the human augmin complex, and they confirmed interaction of HAUS4 with the other 7 augmin subunits by coimmunoprecipitation analysis. Knockdown of HAUS4 or any of the other augmin subunits resulted in destabilization of kinetochore microtubules, formation of multipolar spindles, fragmentation of centrosomes, and increased centrosome size.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant HAUS Augmin Like Complex Subunit 4 (HAUS4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to HAUS Augmin Like Complex Subunit 4 (HAUS4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to HAUS Augmin Like Complex Subunit 4 (HAUS4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for HAUS Augmin Like Complex Subunit 4 (HAUS4) CLIA Kit Customized Service Offer
n/a ELISA Kit for HAUS Augmin Like Complex Subunit 4 (HAUS4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant HAUS Augmin Like Complex Subunit 4 (HAUS4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to HAUS Augmin Like Complex Subunit 4 (HAUS4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to HAUS Augmin Like Complex Subunit 4 (HAUS4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for HAUS Augmin Like Complex Subunit 4 (HAUS4) CLIA Kit Customized Service Offer
n/a ELISA Kit for HAUS Augmin Like Complex Subunit 4 (HAUS4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant HAUS Augmin Like Complex Subunit 4 (HAUS4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to HAUS Augmin Like Complex Subunit 4 (HAUS4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to HAUS Augmin Like Complex Subunit 4 (HAUS4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for HAUS Augmin Like Complex Subunit 4 (HAUS4) CLIA Kit Customized Service Offer
n/a ELISA Kit for HAUS Augmin Like Complex Subunit 4 (HAUS4) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "HAUS, the 8-subunit human augmin complex, regulates centrosome and spindle integrity."Curr. Biol. 19:816-826(2009) [PubMed] [Europe PMC] [Abstract]
  5. "The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells."Proc. Natl. Acad. Sci. U.S.A. 106:6998-7003(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]