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Dynein Assembly Factor 2, Axonemal (DNAAF2)

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KTU; C14orf104; Kintoun

Dynein Assembly Factor 2, Axonemal (DNAAF2)
CCC N581
HGNC 20188
MGI 1923566
PubMed 19492356
RGD 1310311
UniProt Q9NVR5
The KTU gene encodes a protein conserved in animals and ciliated unicellular organisms involved in preassembly of dynein arm complexes in species from algae to humans.
The full-length cDNA of 2,511 basepairs encodes an 837-amino acid protein; a shorter in-frame splice variant lacking exon 2 comprises 2,367 basepairs. RT-PCR analysis detected Ktu expression in medaka embryo and in nearly all organs of adult mice, with higher expression in mouse tissues with motile cilia and flagella such as brain and testis. Ktu localized to the cytoplasm but not the flagellum of sperm. In renal tubules Ktu localized to the apical cytoplasm around the gamma-tubulin-positive pericentriolar region, not in the cilia.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dynein Assembly Factor 2, Axonemal (DNAAF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dynein Assembly Factor 2, Axonemal (DNAAF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dynein Assembly Factor 2, Axonemal (DNAAF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dynein Assembly Factor 2, Axonemal (DNAAF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dynein Assembly Factor 2, Axonemal (DNAAF2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dynein Assembly Factor 2, Axonemal (DNAAF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dynein Assembly Factor 2, Axonemal (DNAAF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dynein Assembly Factor 2, Axonemal (DNAAF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dynein Assembly Factor 2, Axonemal (DNAAF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dynein Assembly Factor 2, Axonemal (DNAAF2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dynein Assembly Factor 2, Axonemal (DNAAF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dynein Assembly Factor 2, Axonemal (DNAAF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dynein Assembly Factor 2, Axonemal (DNAAF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dynein Assembly Factor 2, Axonemal (DNAAF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dynein Assembly Factor 2, Axonemal (DNAAF2) ELISA Kit Customized Service Offer
  1. "Ktu/PF13 is required for cytoplasmic pre-assembly of axonemal dyneins." Nature 456:611-616(2008) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  9. "DYX1C1 is required for axonemal dynein assembly and ciliary motility." Nat. Genet. 45:995-1003(2013) [PubMed] [Europe PMC] [Abstract]
  10. "Ciliary beat pattern and frequency in genetic variants of primary ciliary dyskinesia."Eur. Respir. J. 44:1579-1588(2014) [PubMed] [Europe PMC] [Abstract]