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DDB1 And CUL4 Associated Factor 11 (DCAF11)

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WDR23; WD Repeat Domain 23

DDB1 And CUL4 Associated Factor 11 (DCAF11)
CCC N573
HGNC 20258
MGI 90168
RGD 1311288
UniProt Q8TEB1
The deduced 546- and 520-amino acid WDR23 isoforms differ only in the presence or absence of a 26-amino acid insert near the N terminus. Both isoforms contain 7 WD40 repeats and a conserved DW box motif that overlaps WD40 repeat 5.
The transcription factor Skn1 (POU2F3) protects C. elegans from stress and promotes longevity. Loss of Wdr23 function caused accumulation of Skn1 in intestinal nuclei, elevation of Skn1 protein levels, constitutive transcription of detoxification genes, and increased longevity and stress resistance. Wdr23 interacted with the Ddb1-Cul4 complex and presumably targeted Skn1 for proteasomal degradation.Wdr23 is a negative regulator of Skn1 in C. elegans.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DDB1 And CUL4 Associated Factor 11 (DCAF11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DDB1 And CUL4 Associated Factor 11 (DCAF11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DDB1 And CUL4 Associated Factor 11 (DCAF11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DDB1 And CUL4 Associated Factor 11 (DCAF11) CLIA Kit Customized Service Offer
n/a ELISA Kit for DDB1 And CUL4 Associated Factor 11 (DCAF11) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DDB1 And CUL4 Associated Factor 11 (DCAF11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DDB1 And CUL4 Associated Factor 11 (DCAF11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DDB1 And CUL4 Associated Factor 11 (DCAF11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DDB1 And CUL4 Associated Factor 11 (DCAF11) CLIA Kit Customized Service Offer
n/a ELISA Kit for DDB1 And CUL4 Associated Factor 11 (DCAF11) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DDB1 And CUL4 Associated Factor 11 (DCAF11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DDB1 And CUL4 Associated Factor 11 (DCAF11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DDB1 And CUL4 Associated Factor 11 (DCAF11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DDB1 And CUL4 Associated Factor 11 (DCAF11) CLIA Kit Customized Service Offer
n/a ELISA Kit for DDB1 And CUL4 Associated Factor 11 (DCAF11) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1."Mol. Cell 23:709-721(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery."Nature 443:590-593(2006) [PubMed] [Europe PMC] [Abstract]
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]