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Vacuolar Protein Sorting 36 (VPS36)

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CGI-145; Eap45; C13orf9; ELL-associated protein of 45 kDa; ESCRT-II complex subunit VPS36

Vacuolar Protein Sorting 36 (VPS36)
CCC N565
HGNC 20312
MGI 1917410
PubMed 22880132
RGD 1309754
UniProt Q86VN1
Wiki VPS36
Eap30 (SNF8) and Eap20 (VPS25) could be coimmunoprecipitated in the absence of Eap45, and that Eap20 and Eap45 could be coimmunoprecipitated in the absence of Eap30. However, little Eap30 was coimmunoprecipitated with Eap45 in the absence of Eap20. The Eap45 GLUE domain shares primary and secondary structures with those of the phosphoinositide-binding GRAM and pleckstrin (PLEK) homology (PH) domains.GLUE domain of Eap45 bound ubiquitin with similar affinity and specificity as other ubiquitin-binding domains. The GLUE domain of Eap45 also bound specifically to phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) and more weakly to PtdIns(3,4)P2 and PtdIns(3,5)P2. Eap45 colocalized with ubiquitinated proteins on late endosomes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Vacuolar Protein Sorting 36 (VPS36) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Vacuolar Protein Sorting 36 (VPS36) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vacuolar Protein Sorting 36 (VPS36) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Vacuolar Protein Sorting 36 (VPS36) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vacuolar Protein Sorting 36 (VPS36) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Vacuolar Protein Sorting 36 (VPS36) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Vacuolar Protein Sorting 36 (VPS36) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vacuolar Protein Sorting 36 (VPS36) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Vacuolar Protein Sorting 36 (VPS36) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vacuolar Protein Sorting 36 (VPS36) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Vacuolar Protein Sorting 36 (VPS36) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Vacuolar Protein Sorting 36 (VPS36) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vacuolar Protein Sorting 36 (VPS36) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Vacuolar Protein Sorting 36 (VPS36) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vacuolar Protein Sorting 36 (VPS36) ELISA Kit Customized Service Offer
  1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The protein network of HIV budding."Cell 114:701-713(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins."Proc. Natl. Acad. Sci. U.S.A. 100:12414-12419(2003) [PubMed] [Europe PMC] [Abstract]
  8. ErratumProc. Natl. Acad. Sci. U.S.A. 100:152845-152845(2003)
  9. "RILP interacts with VPS22 and VPS36 of ESCRT-II and regulates their membrane recruitment."Biochem. Biophys. Res. Commun. 350:413-423(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release."J. Virol. 80:9465-9480(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Vps22/EAP30 in ESCRT-II mediates endosomal sorting of growth factor and chemokine receptors destined for lysosomal degradation."Traffic 8:1617-1629(2007) [PubMed] [Europe PMC] [Abstract]
  12. "A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components."J. Biol. Chem. 285:31616-31633(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain."Nat. Struct. Mol. Biol. 13:1029-1030(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Integrated structural model and membrane targeting mechanism of the human ESCRT-II complex."Dev. Cell 14:902-913(2008) [PubMed] [Europe PMC] [Abstract]