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UPF3 Regulator Of Nonsense Transcripts Homolog B (UPF3B)

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RENT3B; UPF3X; HUPF3B; Nonsense mRNA reducing factor 3B; Up-frameshift suppressor 3 homolog B; Up-frameshift suppressor 3 homolog on chromosome X

UPF3 Regulator Of Nonsense Transcripts Homolog B (UPF3B)
CCC N550
HGNC 20439
MGI 1915384
PubMed 23821644
RGD 1560264
UniProt Q9BZI7
Wiki UPF3B
UPF3B encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant UPF3 Regulator Of Nonsense Transcripts Homolog B (UPF3B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to UPF3 Regulator Of Nonsense Transcripts Homolog B (UPF3B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to UPF3 Regulator Of Nonsense Transcripts Homolog B (UPF3B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for UPF3 Regulator Of Nonsense Transcripts Homolog B (UPF3B) CLIA Kit Customized Service Offer
n/a ELISA Kit for UPF3 Regulator Of Nonsense Transcripts Homolog B (UPF3B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant UPF3 Regulator Of Nonsense Transcripts Homolog B (UPF3B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to UPF3 Regulator Of Nonsense Transcripts Homolog B (UPF3B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to UPF3 Regulator Of Nonsense Transcripts Homolog B (UPF3B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for UPF3 Regulator Of Nonsense Transcripts Homolog B (UPF3B) CLIA Kit Customized Service Offer
n/a ELISA Kit for UPF3 Regulator Of Nonsense Transcripts Homolog B (UPF3B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant UPF3 Regulator Of Nonsense Transcripts Homolog B (UPF3B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to UPF3 Regulator Of Nonsense Transcripts Homolog B (UPF3B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to UPF3 Regulator Of Nonsense Transcripts Homolog B (UPF3B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for UPF3 Regulator Of Nonsense Transcripts Homolog B (UPF3B) CLIA Kit Customized Service Offer
n/a ELISA Kit for UPF3 Regulator Of Nonsense Transcripts Homolog B (UPF3B) ELISA Kit Customized Service Offer
  1. "Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon."Cell 103:1121-1131(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4)."Mol. Cell. Biol. 21:209-223(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex."Science 293:1832-1836(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1."Science 293:1836-1839(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Y14 and hUpf3b form an NMD-activating complex."Mol. Cell 11:939-949(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1."RNA 9:77-87(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements."Mol. Cell 20:65-75(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation."RNA 12:1015-1022(2006) [PubMed] [Europe PMC] [Abstract]
  10. "NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity."Nat. Struct. Mol. Biol. 15:85-93(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  16. "The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3."Nat. Struct. Mol. Biol. 11:330-337(2004) [PubMed] [Europe PMC] [Abstract]
  17. "Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex."Proc. Natl. Acad. Sci. U.S.A. 107:10050-10055(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation." Nat. Genet. 39:1127-1133(2007) [PubMed] [Europe PMC] [Abstract]