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Structural Maintenance Of Chromosomes Protein 6 (SMC6)

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SMC6L1; SMC6 Structural Maintenance Of Chromosomes 6-Like 1

Structural Maintenance Of Chromosomes Protein 6 (SMC6)
CCC N547
HGNC 20466
MGI 1914491
PubMed 23907463
RGD 1311214
UniProt Q96SB8
Wiki SMC6
Torres-Rosell et al. (2005) found that Smc5 (SMC5L1) and Smc6 in S. cerevisiae are enriched at nucleolar ribosomal DNA (rDNA) and at some telomeres. Mutant Smc5/Smc6 cells underwent an aberrant mitosis in which chromosome segregation of repetitive regions was impaired, leading to DNA damage and Rad9 -dependent activation of the Rad53 (CHEK2) protein kinase.
Following Smc5/Smc6 inactivation, metaphase-arrested cells showed increased levels of X-shaped DNA (Holliday junctions) at the rDNA locus. Torres-Rosell et al. (2005) concluded that the SMC5/SMC6 complex prevents the formation of sister chromatid junctions, thereby ensuring the correct partitioning of chromosomes during anaphase.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Structural Maintenance Of Chromosomes Protein 6 (SMC6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Structural Maintenance Of Chromosomes Protein 6 (SMC6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Structural Maintenance Of Chromosomes Protein 6 (SMC6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Structural Maintenance Of Chromosomes Protein 6 (SMC6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Structural Maintenance Of Chromosomes Protein 6 (SMC6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Structural Maintenance Of Chromosomes Protein 6 (SMC6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Structural Maintenance Of Chromosomes Protein 6 (SMC6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Structural Maintenance Of Chromosomes Protein 6 (SMC6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Structural Maintenance Of Chromosomes Protein 6 (SMC6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Structural Maintenance Of Chromosomes Protein 6 (SMC6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Structural Maintenance Of Chromosomes Protein 6 (SMC6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Structural Maintenance Of Chromosomes Protein 6 (SMC6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Structural Maintenance Of Chromosomes Protein 6 (SMC6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Structural Maintenance Of Chromosomes Protein 6 (SMC6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Structural Maintenance Of Chromosomes Protein 6 (SMC6) ELISA Kit Customized Service Offer
  1. "Characterization of a novel human SMC heterodimer homologous to the Schizosaccharomyces pombe Rad18/Spr18 complex."Mol. Biol. Cell 12:1583-1594(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Coordination of DNA damage responses via the Smc5/Smc6 complex."Mol. Cell. Biol. 24:662-674(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Human MMS21/NSE2 is a SUMO ligase required for DNA repair."Mol. Cell. Biol. 25:7021-7032(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks."EMBO J. 25:3377-3388(2006) [PubMed] [Europe PMC] [Abstract]
  10. "The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins."Nat. Struct. Mol. Biol. 14:581-590(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex."Mol. Cell. Biol. 28:1197-1206(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]