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Cardiac Zipper Protein (CAZIP)

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MTUS2; TIP150; TIP Of 150 kDa; Microtubule Associated Tumor Suppressor Candidate 2; Microtubule plus-end tracking protein TIP150

Cardiac Zipper Protein (CAZIP)
CCC N534
HGNC 20595
MGI 1915388
PubMed 21865998
UniProt Q5JR59
A whole genome micro-array analysis on human embryonic stem cells differentiating toward cardiomyocytes, which resulted in the identification of novel genes that were highly up-regulated during differentiation. The predicted protein contains a leucine-zipper domain at the C-terminus and has at least two isoforms. Whole-mount in situ hybridization confirmed that the mRNA of both the mouse and chicken orthologs of KIAA0774 is expressed during early cardiac development.Later during embryonic development, Cazip was also expressed in parts of the nervous system. Northern blot and real-time polymerase chain reaction analysis showed that Cazip is expressed in heart and brain in adult mice. These results suggest a role for CAZIP in development and function of the heart and nervous system in vertebrates.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cardiac Zipper Protein (CAZIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cardiac Zipper Protein (CAZIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cardiac Zipper Protein (CAZIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cardiac Zipper Protein (CAZIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cardiac Zipper Protein (CAZIP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cardiac Zipper Protein (CAZIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cardiac Zipper Protein (CAZIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cardiac Zipper Protein (CAZIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cardiac Zipper Protein (CAZIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cardiac Zipper Protein (CAZIP) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "CAZIP, a novel protein expressed in the developing heart and nervous system."Dev. Dyn. 238:2903-2911(2009) [PubMed] [Europe PMC] [Abstract]
  6. "TIP150 interacts with and targets MCAK at the microtubule plus ends."EMBO Rep. 10:857-865(2009) [PubMed] [Europe PMC] [Abstract]