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DIS3 Mitotic Control Homolog (DIS3)

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Dis3p; RRP44; EXOSC11; Exosome Component 11; Ribosomal RNA-processing protein 44

DIS3 Mitotic Control Homolog (DIS3)
CCC N532
HGNC 20604
MGI 1919912
PubMed 17173052
RGD 1304646
UniProt Q9Y2L1
Wiki DIS3
By randomly sequencing clones obtained from a size-fractionated brain cDNA library, Nagase et al. (1999) cloned DIS3, which they designated KIAA1008. The deduced 928-amino acid protein shares 44.5% identity with the mitotic control protein Dis3 of S. pombe. PCR-ELISA detected low to moderate expression in all tissues and brain regions tested, with highest expression in testis and moderate expression in kidney, ovary, corpus callosum, spinal cord, and fetal brain.
By sequence analysis of chromosome 13q21-q22 to identify a breast cancer susceptibility gene, Rozenblum et al. (2002) identified DIS3. The deduced protein contains 958 amino acids. Northern blot analysis detected ubiquitous expression.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DIS3 Mitotic Control Homolog (DIS3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DIS3 Mitotic Control Homolog (DIS3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DIS3 Mitotic Control Homolog (DIS3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DIS3 Mitotic Control Homolog (DIS3) CLIA Kit Customized Service Offer
n/a ELISA Kit for DIS3 Mitotic Control Homolog (DIS3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DIS3 Mitotic Control Homolog (DIS3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DIS3 Mitotic Control Homolog (DIS3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DIS3 Mitotic Control Homolog (DIS3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DIS3 Mitotic Control Homolog (DIS3) CLIA Kit Customized Service Offer
n/a ELISA Kit for DIS3 Mitotic Control Homolog (DIS3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DIS3 Mitotic Control Homolog (DIS3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DIS3 Mitotic Control Homolog (DIS3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DIS3 Mitotic Control Homolog (DIS3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DIS3 Mitotic Control Homolog (DIS3) CLIA Kit Customized Service Offer
n/a ELISA Kit for DIS3 Mitotic Control Homolog (DIS3) ELISA Kit Customized Service Offer
  1. "Human dis3p, which binds to either GTP- or GDP-Ran, complements Saccharomyces cerevisiae dis3."J. Biochem. 123:883-890(1998) [PubMed] [Europe PMC] [Abstract]
  2. ErratumJ. Biochem. 124:250-250(1998)
  3. "A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes." Hum. Genet. 110:111-121(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  8. "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  10. "RNA exosome depletion reveals transcription upstream of active human promoters."Science 322:1851-1854(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Functional proteomic analysis of human nucleolus."Mol. Biol. Cell 13:4100-4109(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  13. "The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L."EMBO J. 29:2342-2357(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Dis3-like 1: a novel exoribonuclease associated with the human exosome."EMBO J. 29:2358-2367(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]