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Solute Carrier Family 25, Member 24 (SLC25A24)

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APC1; SCAMC1; MCSC1; Mitochondrial Ca(2+)-dependent solute carrier protein 1; Small calcium-binding mitochondrial carrier protein 1; Mitochondrial ATP-Mg/Pi carrier protein 1

Solute Carrier Family 25, Member 24 (SLC25A24)
CCC N527
HGNC 20662
MGI 1917160
PubMed 23933412
RGD 1311982
UniProt Q6NUK1
The calcium-binding domain shares 25% identity with calmodulin , with 4 EF-hand motifs at conserved positions. SCAMC1 also shares significant similarity with SCAMC2 (SLC25A25) and SCAMC3 (SLC25A23), with most differences in the N termini and EF-hand 1.
Northern blot analysis detected a 3.4-kb SCAMC1 transcript in all tissues examined, and expression of SCAMC1 was generally higher than that of SCAMC2 or SCAMC3. Both endogenous and transfected epitope-tagged SCAMC1 were expressed in a subcellular pattern that overlapped with a mitochondrial marker. Western blot analysis of mitochondria-enriched fractions of a number of cell lines showed that SCAMC1 migrated at an apparent molecular mass of 48 to 50 kD.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Solute Carrier Family 25, Member 24 (SLC25A24) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Solute Carrier Family 25, Member 24 (SLC25A24) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Solute Carrier Family 25, Member 24 (SLC25A24) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Solute Carrier Family 25, Member 24 (SLC25A24) CLIA Kit Customized Service Offer
n/a ELISA Kit for Solute Carrier Family 25, Member 24 (SLC25A24) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Solute Carrier Family 25, Member 24 (SLC25A24) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Solute Carrier Family 25, Member 24 (SLC25A24) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Solute Carrier Family 25, Member 24 (SLC25A24) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Solute Carrier Family 25, Member 24 (SLC25A24) CLIA Kit Customized Service Offer
n/a ELISA Kit for Solute Carrier Family 25, Member 24 (SLC25A24) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Solute Carrier Family 25, Member 24 (SLC25A24) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Solute Carrier Family 25, Member 24 (SLC25A24) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Solute Carrier Family 25, Member 24 (SLC25A24) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Solute Carrier Family 25, Member 24 (SLC25A24) CLIA Kit Customized Service Offer
n/a ELISA Kit for Solute Carrier Family 25, Member 24 (SLC25A24) ELISA Kit Customized Service Offer
  1. "Identification of a novel human subfamily of mitochondrial carriers with calcium-binding domains."J. Biol. Chem. 279:24701-24713(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of the mitochondrial ATP-Mg/Pi transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution."J. Biol. Chem. 279:30722-30730(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "SCaMC-1 promotes cancer cell survival by desensitizing mitochondrial permeability transition via ATP/ADP-mediated matrix Ca(2+) buffering."Cell Death Differ. 19:650-660(2012) [PubMed] [Europe PMC] [Abstract]
  9. "A self-sequestered calmodulin-like Ca(2+) sensor of mitochondrial SCaMC carrier and its implication to Ca(2+)-dependent ATP-Mg/Pi transport."Structure 22:209-217(2014) [PubMed] [Europe PMC] [Abstract]