≡

Zinc Finger, FYVE Domain Containing Protein 16 (ZFYVE16)

[Edit]

Endofin; Endosome-associated FYVE domain protein

Zinc Finger, FYVE Domain Containing Protein 16 (ZFYVE16)
CCC N525
HGNC 20756
MGI 2145181
PubMed 20515759
RGD 1564784
UniProt Q7Z3T8
Wiki ZFYVE16
Endofin is expressed in early endosomes, similar to EEA1. Expression constructs of truncated endofin showed that the FYVE domain is required for endosomal expression, and treatment with the PI3-kinase inhibitor wortmannin showed that endosomal localization of endofin is dependent on PI3-kinase activity. While indirect immunofluorescence showed colocalization of endofin and SARA, coimmunoprecipitation experiments demonstrated that the 2 proteins do not associate with each other.
Unlike SARA, endofin does not affect TGF-beta-induced transcriptional activity. Overexpression of endofin caused endosomal aggregate formation, and these aggregates accumulated EGF and prevented its degradation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger, FYVE Domain Containing Protein 16 (ZFYVE16) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger, FYVE Domain Containing Protein 16 (ZFYVE16) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger, FYVE Domain Containing Protein 16 (ZFYVE16) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger, FYVE Domain Containing Protein 16 (ZFYVE16) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger, FYVE Domain Containing Protein 16 (ZFYVE16) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger, FYVE Domain Containing Protein 16 (ZFYVE16) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger, FYVE Domain Containing Protein 16 (ZFYVE16) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger, FYVE Domain Containing Protein 16 (ZFYVE16) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger, FYVE Domain Containing Protein 16 (ZFYVE16) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger, FYVE Domain Containing Protein 16 (ZFYVE16) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger, FYVE Domain Containing Protein 16 (ZFYVE16) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger, FYVE Domain Containing Protein 16 (ZFYVE16) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger, FYVE Domain Containing Protein 16 (ZFYVE16) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger, FYVE Domain Containing Protein 16 (ZFYVE16) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger, FYVE Domain Containing Protein 16 (ZFYVE16) ELISA Kit Customized Service Offer
  1. "Endofin, an endosomal FYVE domain protein."J. Biol. Chem. 276:42445-42454(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Endofin recruits TOM1 to endosomes."J. Biol. Chem. 279:4670-4679(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  9. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Crystal structure of the FYVE domain of endofin (ZFYVE16) at 1.1A resolution."Submitted (AUG-2011) to the PDB data bank
  15. "Diagnostic exome sequencing in persons with severe intellectual disability."N. Engl. J. Med. 367:1921-1929(2012) [PubMed] [Europe PMC] [Abstract]