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Zinc Finger, FYVE Domain Containing Protein 26 (ZFYVE26)

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SPG15; FYVE-CENT; Spastizin; Spastic Paraplegia 15; FYVE domain-containing centrosomal protein

Zinc Finger, FYVE Domain Containing Protein 26 (ZFYVE26)
CCC N524
HGNC 20761
MGI 1924767
PubMed 24284334
RGD 1307820
UniProt Q68DK2
RT-PCR detected ZFYVE26 expression in all tissues examined. Highest expression was in ovary, followed by placenta, lung, and kidney. In vitro-translated ZFYVE26 had an apparent molecular mass of more than 100 kD by SDS-PAGE.The 2,539-residue protein has a 9.7-kb mRNA transcript and is expressed in various human tissues, particularly adrenal gland, bone marrow, adult brain, fetal brain, lung, placenta, prostate, skeletal muscle, testis, thymus, and retina. In situ hybridization showed wider and stronger Zfyve26 expression in embryonic rat brain compared to adult rat brain, particularly in the spinal cord and cortical, cerebellar, thalamic, and hippocampal neuroepithelia. In COS-7 cells, ZFYVE26 colocalized partially with markers of endoplasmic reticulum and endosomes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger, FYVE Domain Containing Protein 26 (ZFYVE26) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger, FYVE Domain Containing Protein 26 (ZFYVE26) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger, FYVE Domain Containing Protein 26 (ZFYVE26) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger, FYVE Domain Containing Protein 26 (ZFYVE26) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger, FYVE Domain Containing Protein 26 (ZFYVE26) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger, FYVE Domain Containing Protein 26 (ZFYVE26) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger, FYVE Domain Containing Protein 26 (ZFYVE26) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger, FYVE Domain Containing Protein 26 (ZFYVE26) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger, FYVE Domain Containing Protein 26 (ZFYVE26) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger, FYVE Domain Containing Protein 26 (ZFYVE26) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger, FYVE Domain Containing Protein 26 (ZFYVE26) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger, FYVE Domain Containing Protein 26 (ZFYVE26) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger, FYVE Domain Containing Protein 26 (ZFYVE26) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger, FYVE Domain Containing Protein 26 (ZFYVE26) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger, FYVE Domain Containing Protein 26 (ZFYVE26) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of the SPG15 gene, encoding spastizin, as a frequent cause of complicated autosomal-recessive spastic paraplegia, including Kjellin syndrome."Am. J. Hum. Genet. 82:992-1002(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Spastic paraplegia with thinning of the corpus callosum and white matter abnormalities: further mutations and relative frequency in ZFYVE26/SPG15 in the Italian population." J. Neurol. Sci. 277:22-25(2009) [PubMed] [Europe PMC] [Abstract]
  9. "SPG15 is the second most common cause of hereditary spastic paraplegia with thin corpus callosum." Neurology 73:1111-1119(2009) [PubMed] [Europe PMC] [Abstract]
  10. "PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody."Nat. Cell Biol. 12:362-371(2010) [PubMed] [Europe PMC] [Abstract]
  11. "A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia." PLoS Biol. 8:E1000408-E1000408(2010) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  13. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]