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Cation Channel, Sperm Associated 3 (CATSPER3)

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CACRC; Ca(v)-like protein; One-repeat calcium channel-like protein

Cation Channel, Sperm Associated 3 (CATSPER3)
CCC N516
HGNC 20819
MGI 1924106
PubMed 17344468
RGD 1305700
UniProt Q86XQ3
Wiki CatSper3
CATSPER3 gene contains 8 exons and spans 43.7 kb. The intronic sequences of the CATSPER3 gene contain numerous repeats, including Alu and LINE repeats.
The deduced 398-amino acid protein has a calculated molecular mass of 46.4 kD. CATSPER3 contains 6 transmembrane segments and shares similarity with 1 repeat of the 4-repeat voltage-gated Ca(2+) channels. Northern blot analysis detected a 1.4-kb transcript only in testis. mRNA dot blot analysis detected CATSPER3 expression in a wide variety of tissues, with highest expression in testis. Fluorescence-tagged CATSPER3 localized predominantly to the nucleus of human embryonic kidney cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cation Channel, Sperm Associated 3 (CATSPER3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cation Channel, Sperm Associated 3 (CATSPER3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cation Channel, Sperm Associated 3 (CATSPER3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cation Channel, Sperm Associated 3 (CATSPER3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cation Channel, Sperm Associated 3 (CATSPER3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cation Channel, Sperm Associated 3 (CATSPER3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cation Channel, Sperm Associated 3 (CATSPER3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cation Channel, Sperm Associated 3 (CATSPER3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cation Channel, Sperm Associated 3 (CATSPER3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cation Channel, Sperm Associated 3 (CATSPER3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cation Channel, Sperm Associated 3 (CATSPER3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cation Channel, Sperm Associated 3 (CATSPER3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cation Channel, Sperm Associated 3 (CATSPER3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cation Channel, Sperm Associated 3 (CATSPER3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cation Channel, Sperm Associated 3 (CATSPER3) ELISA Kit Customized Service Offer
  1. "Cloning of a novel one-repeat calcium channel-like gene."Biochem. Biophys. Res. Commun. 303:31-36(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Identification of human and mouse CatSper3 and CatSper4 genes: characterisation of a common interaction domain and evidence for expression in testis."Reprod. Biol. Endocrinol. 1:53-53(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Expression of CatSper family transcripts in the mouse testis during post-natal development and human ejaculated spermatozoa: relationship to sperm motility."Mol. Hum. Reprod. 13:299-306(2007) [PubMed] [Europe PMC] [Abstract]
  5. "The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm."Nature 471:382-386(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Progesterone activates the principal Ca2+ channel of human sperm."Nature 471:387-391(2011) [PubMed] [Europe PMC] [Abstract]