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Biogenesis Of Lysosomal Organelles Complex 1, Subunit 3 (BLOC1S3)

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BLOS3; BLOC-1 Subunit 3; Biogenesis Of Lysosome Related Organelles Complex 1 Subunit 3

Biogenesis Of Lysosomal Organelles Complex 1, Subunit 3 (BLOC1S3)
CCC N505
HGNC 20914
MGI 98000
PubMed 16385460
RGD 1591724
UniProt Q6QNY0
BLOC1S3 is a component of the ubiquitously expressed BLOC1 multisubunit protein complex. BLOC1 is required for normal biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The deduced BLOS3 protein has a calculated molecular mass of 21.3 kD. However, Western blot analysis detected endogenous HeLa cell BLOS3 at an apparent molecular mass of 32 kD.
Other BLOC1 subunits identified were pallidin, muted, dysbindin (DTNBP1), cappuccino, snapin (SNAPAP), BLOC1S1, and BLOC1S2. Coimmunoprecipitation and yeast 2-hybrid analyses confirmed that these proteins interact within the BLOC1 complex.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Biogenesis Of Lysosomal Organelles Complex 1, Subunit 3 (BLOC1S3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Biogenesis Of Lysosomal Organelles Complex 1, Subunit 3 (BLOC1S3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Biogenesis Of Lysosomal Organelles Complex 1, Subunit 3 (BLOC1S3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Biogenesis Of Lysosomal Organelles Complex 1, Subunit 3 (BLOC1S3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Biogenesis Of Lysosomal Organelles Complex 1, Subunit 3 (BLOC1S3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Biogenesis Of Lysosomal Organelles Complex 1, Subunit 3 (BLOC1S3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Biogenesis Of Lysosomal Organelles Complex 1, Subunit 3 (BLOC1S3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Biogenesis Of Lysosomal Organelles Complex 1, Subunit 3 (BLOC1S3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Biogenesis Of Lysosomal Organelles Complex 1, Subunit 3 (BLOC1S3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Biogenesis Of Lysosomal Organelles Complex 1, Subunit 3 (BLOC1S3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Biogenesis Of Lysosomal Organelles Complex 1, Subunit 3 (BLOC1S3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Biogenesis Of Lysosomal Organelles Complex 1, Subunit 3 (BLOC1S3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Biogenesis Of Lysosomal Organelles Complex 1, Subunit 3 (BLOC1S3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Biogenesis Of Lysosomal Organelles Complex 1, Subunit 3 (BLOC1S3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Biogenesis Of Lysosomal Organelles Complex 1, Subunit 3 (BLOC1S3) ELISA Kit Customized Service Offer
  1. "Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1)."J. Biol. Chem. 279:28393-28401(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "A germline mutation in BLOC1S3/reduced pigmentation causes a novel variant of Hermansky-Pudlak syndrome (HPS8)."Am. J. Hum. Genet. 78:160-166(2006) [PubMed] [Europe PMC] [Abstract]
  5. "BLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organelles."Mol. Biol. Cell 18:768-780(2007) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Assembly and architecture of biogenesis of lysosome-related organelles complex-1 (BLOC-1)."J. Biol. Chem. 287:5882-5890(2012) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]