Histocompatibility Serpin Domain Containing Protein (HMSD)

HMSD was selectively expressed at higher levels in mature dendritic cells and primary leukemia cells, particularly those of myeloid lineage. In contrast, most normal tissues and resting hematopoietic cells showed low or no expression, except for testis, where expression was moderate.

RT-PCR analysis showed that, like HMSD, HMSDv was selectively expressed at higher levels in mature dendritic cells and primary leukemia cells, particularly those of myeloid lineage. Engraftment of mHA-expressing myeloid leukemia stem cells into nonobese diabetic/severe combined immunodeficient/Il2rg-null mice was inhibited by preincubation with patient posttransplant CTLs, but not pretransplant CTLs.