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LMBR1 Domain Containing Protein 1 (LMBRD1)

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NESI; cblF; LMBD1; C6orf209; HDAg-L-interacting protein NESI; Probable lysosomal cobalamin transporter; Nuclear export signal-interacting protein

LMBR1 Domain Containing Protein 1 (LMBRD1)
CCC N486
HGNC 23038
MGI 1915671
PubMed 24078630
RGD 708471
UniProt Q9NUN5
Wiki LMBRD1
The protein encoded by LMBRD1, which the authors called LMBD1, contains 540 amino acids and has a calculated molecular mass of 61.4 kD. It contains 9 predicted transmembrane domains and 6 putative N-glycosylation sites. In transfected HeLa cells and primary human fibroblasts, fluorescence-tagged LMBD1 exhibited a punctate distribution throughout the cytoplasm and perinuclear region that colocalized with a lysosomal marker.
Electron microscopy and immunogold labeling showed that LMBD1 localized to the lysosomal membrane. Analysis of LMBD1 glycosylation status confirmed that LMBD1 has 9 transmembrane helices, with an N terminus in the lysosomal interior and a cytoplasmic C terminus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant LMBR1 Domain Containing Protein 1 (LMBRD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to LMBR1 Domain Containing Protein 1 (LMBRD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to LMBR1 Domain Containing Protein 1 (LMBRD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for LMBR1 Domain Containing Protein 1 (LMBRD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for LMBR1 Domain Containing Protein 1 (LMBRD1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant LMBR1 Domain Containing Protein 1 (LMBRD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to LMBR1 Domain Containing Protein 1 (LMBRD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to LMBR1 Domain Containing Protein 1 (LMBRD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for LMBR1 Domain Containing Protein 1 (LMBRD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for LMBR1 Domain Containing Protein 1 (LMBRD1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant LMBR1 Domain Containing Protein 1 (LMBRD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to LMBR1 Domain Containing Protein 1 (LMBRD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to LMBR1 Domain Containing Protein 1 (LMBRD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for LMBR1 Domain Containing Protein 1 (LMBRD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for LMBR1 Domain Containing Protein 1 (LMBRD1) ELISA Kit Customized Service Offer
  1. "Novel nuclear export signal-interacting protein, NESI, critical for the assembly of hepatitis delta virus."J. Virol. 79:8113-8120(2005) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of a putative lysosomal cobalamin exporter altered in the cblF defect of vitamin B12 metabolism."Nat. Genet. 41:234-239(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]