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Novel LZAP Binding Protein (NLBP)

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UFL1; RCAD; Regulator of C53/LZAP and DDRGK1; E3 UFM1-protein ligase 1

Novel LZAP Binding Protein (NLBP)
CCC N485
HGNC 23039
MGI 1914740
PubMed 22506236
RGD 1309308
UniProt O94874
NLBP and LZAP colocalized in the cytoplasm. Both proteins were subject to ubiquitination, and they appeared to stabilize each other against ubiquitination and degradation via the proteasome.
Domain analysis revealed that an N-terminal region of NLBP and a central region of LZAP were required for the interaction. Knockdown of either NLBP or LZAP via small interfering RNA increased expression of MMP9 and the invasiveness of U2OS cells. Western blot analysis detected reduced levels of LZAP and NLBP in several invasive hepatocellular carcinoma cell lines, but not in a noninvasive cell line. NLBP inhibited the NF-kappa-B signaling pathway.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Novel LZAP Binding Protein (NLBP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Novel LZAP Binding Protein (NLBP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Novel LZAP Binding Protein (NLBP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Novel LZAP Binding Protein (NLBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Novel LZAP Binding Protein (NLBP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Novel LZAP Binding Protein (NLBP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Novel LZAP Binding Protein (NLBP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Novel LZAP Binding Protein (NLBP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Novel LZAP Binding Protein (NLBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Novel LZAP Binding Protein (NLBP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Novel LZAP Binding Protein (NLBP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Novel LZAP Binding Protein (NLBP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Novel LZAP Binding Protein (NLBP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Novel LZAP Binding Protein (NLBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Novel LZAP Binding Protein (NLBP) ELISA Kit Customized Service Offer
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  7. "A novel type of E3 ligase for the Ufm1 conjugation system."J. Biol. Chem. 285:5417-5427(2010) [PubMed] [Europe PMC] [Abstract]
  8. "A novel LZAP-binding protein, NLBP, inhibits cell invasion."J. Biol. Chem. 285:12232-12240(2010) [PubMed] [Europe PMC] [Abstract]
  9. "A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling."J. Biol. Chem. 285:15126-15136(2010) [PubMed] [Europe PMC] [Abstract]
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  13. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  15. "Modification of ASC1 by UFM1 is crucial for ERalpha transactivation and breast cancer development."Mol. Cell 56:261-274(2014) [PubMed] [Europe PMC] [Abstract]