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Nanos Homolog 1 (NANOS1)

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NOS1; EC_Rep1a

Nanos Homolog 1 (NANOS1)
CCC N484
HGNC 23044
MGI 2669254
PubMed 12834871
RGD 1308194
UniProt Q8WY41
The deduced 292-amino acid protein has a calculated molecular mass of 32 kD. The C terminus contains a conserved RNA-binding domain that consist of 2 zinc fingers of about 52 amino acids. The NOS1 transcript has a long 3-prime untranslated region. Database analysis detected homologous proteins in several vertebrate and invertebrate species, and the zinc finger region of NANOS1 shares 62% identity with the zinc finger region of Drosophila Nanos. Northern blot analysis detected a 2.0-kb transcript expressed exclusively in testis. RT-PCR also detected expression in embryonic stem cells and in fetal testis and fetal ovary. Immunohistochemical localization of NOS1 in adult testis detected abundant expression in spermatogonia, with strongest staining in the perinuclear cytoplasm. Like PUM2, NOS1 was expressed during meiosis in spermatocytes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nanos Homolog 1 (NANOS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nanos Homolog 1 (NANOS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nanos Homolog 1 (NANOS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nanos Homolog 1 (NANOS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nanos Homolog 1 (NANOS1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nanos Homolog 1 (NANOS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nanos Homolog 1 (NANOS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nanos Homolog 1 (NANOS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nanos Homolog 1 (NANOS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nanos Homolog 1 (NANOS1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nanos Homolog 1 (NANOS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nanos Homolog 1 (NANOS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nanos Homolog 1 (NANOS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nanos Homolog 1 (NANOS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nanos Homolog 1 (NANOS1) ELISA Kit Customized Service Offer
  1. "Conservation of a Pumilio-Nanos complex from Drosophila germ plasm to human germ cells."Dev. Genes Evol. 213:120-126(2003) [PubMed] [Europe PMC] [Abstract]
  2. "E-cadherin regulates human Nanos1, which interacts with p120ctn and induces tumor cell migration and invasion."Cancer Res. 66:10007-10015(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The E-cadherin-repressed hNanos1 gene induces tumor cell invasion by upregulating MT1-MMP expression."Oncogene 27:3692-3699(2008) [PubMed] [Europe PMC] [Abstract]
  5. "The SNARE-associated component SNAPIN binds PUMILIO2 and NANOS1 proteins in human male germ cells."Mol. Hum. Reprod. 15:173-179(2009) [PubMed] [Europe PMC] [Abstract]
  6. "NANOS1 and PUMILIO2 bind microRNA biogenesis factor GEMIN3, within chromatoid body in human germ cells."Histochem. Cell Biol. 136:279-287(2011) [PubMed] [Europe PMC] [Abstract]
  7. "NANOS3 function in human germ cell development."Hum. Mol. Genet. 20:2238-2250(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Mutations of NANOS1, a human homologue of the Drosophila morphogen, are associated with a lack of germ cells in testes or severe oligo-astheno-teratozoospermia."J. Med. Genet. 50:187-193(2013) [PubMed] [Europe PMC] [Abstract]