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Bub1 Related Kinase (BRK1)

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HSPC300; BRICK1; C3orf10

Bub1 Related Kinase (BRK1)
CCC N480
HGNC 23057
MGI 1915406
PubMed 23243128
RGD 1598136
UniProt Q8WUW1
The C3ORF10 gene encodes a 9-kD protein involved in the complex process of actin nucleation.Eden et al. (2002) purified a multiprotein complex from bovine brain containing orthologs of human WAVE1 (WASF1), PIR121, NAP125, and HSPC300. Whereas recombinant WAVE1 is constitutively active, the WAVE1 complex is inactive. Actin polymerization studies suggested that RAC1 and NCK cause dissociation of the WAVE1 complex, which releases active WAVE1-HSPC300 and leads to actin nucleation.
Gautreau et al. (2004) purified WAVE2 from HeLa cells and determined that it associated in a complex with several other proteins, including HSPC300. HSPC300 showed direct interaction with the WAVE2 protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bub1 Related Kinase (BRK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bub1 Related Kinase (BRK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bub1 Related Kinase (BRK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bub1 Related Kinase (BRK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bub1 Related Kinase (BRK1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bub1 Related Kinase (BRK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bub1 Related Kinase (BRK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bub1 Related Kinase (BRK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bub1 Related Kinase (BRK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bub1 Related Kinase (BRK1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bub1 Related Kinase (BRK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bub1 Related Kinase (BRK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bub1 Related Kinase (BRK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bub1 Related Kinase (BRK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bub1 Related Kinase (BRK1) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Purification and architecture of the ubiquitous Wave complex."Proc. Natl. Acad. Sci. U.S.A. 101:4379-4383(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Free Brick1 is a trimeric precursor in the assembly of a functional wave complex."PLoS ONE 3:E2462-E2462(2008) [PubMed] [Europe PMC] [Abstract]
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  8. "Structure and control of the actin regulatory WAVE complex."Nature 468:533-538(2010) [PubMed] [Europe PMC] [Abstract]