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Mediator Complex Subunit 29 (MED29)

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IXL; Mediator of RNA polymerase II transcription subunit 29; Intersex-like protein

Mediator Complex Subunit 29 (MED29)
CCC N477
HGNC 23074
MGI 1914474
PubMed 21225629
RGD 1311009
UniProt Q9NX70
MED29 is a subunit of the Mediator complex, a multiprotein coactivator of RNA transcription that interacts with DNA-bound transcriptional activators, RNA polymerase II , and general initiation factors.
The deduced 221-amino acid protein has a calculated molecular mass of 23.5 kD. It contains a PxxP motif for binding SRC homology-3 (SH3) domains. IXL is highly conserved across a wide range of species, and it shares 92% amino acid identity with mouse Ixl and 36% identity with Drosophila Intersex. Northern blot analysis detected a 3.6-kb transcript expressed at variable levels in all adult and fetal human tissues examined. Fluorescence-tagged IXL localized predominantly to the nucleus, but also to the cytoplasm, of transfected COS-7 cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mediator Complex Subunit 29 (MED29) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mediator Complex Subunit 29 (MED29) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mediator Complex Subunit 29 (MED29) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mediator Complex Subunit 29 (MED29) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mediator Complex Subunit 29 (MED29) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mediator Complex Subunit 29 (MED29) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mediator Complex Subunit 29 (MED29) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mediator Complex Subunit 29 (MED29) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mediator Complex Subunit 29 (MED29) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mediator Complex Subunit 29 (MED29) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mediator Complex Subunit 29 (MED29) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mediator Complex Subunit 29 (MED29) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mediator Complex Subunit 29 (MED29) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mediator Complex Subunit 29 (MED29) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mediator Complex Subunit 29 (MED29) ELISA Kit Customized Service Offer
  1. "IXL, a new subunit of the mammalian Mediator complex, functions as a transcriptional suppressor."Biochem. Biophys. Res. Commun. 325:1330-1338(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex."J. Biol. Chem. 278:49671-49674(2003) [PubMed] [Europe PMC] [Abstract]
  7. "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2."J. Biol. Chem. 279:5846-5851(2004) [PubMed] [Europe PMC] [Abstract]
  8. "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."Mol. Cell 14:685-691(2004) [PubMed] [Europe PMC] [Abstract]
  9. "MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."Mol. Cell 19:89-100(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]