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FAT Tumor Suppressor Homolog 4 (FAT4)

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CDHF14; FAT-J; CDHR11; Cadherin-Related Family Member 14; Fat-like cadherin protein FAT-J ; Protocadherin Fat 4

FAT Tumor Suppressor Homolog 4 (FAT4)
CCC N471
HGNC 23109
MGI 3045256
PubMed 18604206
RGD 1564291
UniProt Q6V0I7
Wiki FAT4
Fat4 is an essential gene that has a key role in vertebrate planar cell polarity (PCP). Loss of Fat4 disturbed oriented cell divisions and tubule elongation during kidney development, leading to cystic kidney disease. Fat4 genetically interacts with the PCP genes Vangl2 and Fjx1 in cyst formation.
In addition, Fat4 represses Fjx1 expression, indicating that signaling is conserved. taken together, their data suggested that FAT4 regulates vertebrate PCP and that loss of PCP signaling may underlie some cystic diseases in humans.In silico analysis identified FAT4 mRNAs in fetal brain, infant brain, brain tumor, and colorectal cancer. Phylogenetic analysis revealed that FAT4 is divergent from FAT1, FAT2, and FAT3.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant FAT Tumor Suppressor Homolog 4 (FAT4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to FAT Tumor Suppressor Homolog 4 (FAT4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to FAT Tumor Suppressor Homolog 4 (FAT4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for FAT Tumor Suppressor Homolog 4 (FAT4) CLIA Kit Customized Service Offer
n/a ELISA Kit for FAT Tumor Suppressor Homolog 4 (FAT4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant FAT Tumor Suppressor Homolog 4 (FAT4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to FAT Tumor Suppressor Homolog 4 (FAT4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to FAT Tumor Suppressor Homolog 4 (FAT4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for FAT Tumor Suppressor Homolog 4 (FAT4) CLIA Kit Customized Service Offer
n/a ELISA Kit for FAT Tumor Suppressor Homolog 4 (FAT4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant FAT Tumor Suppressor Homolog 4 (FAT4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to FAT Tumor Suppressor Homolog 4 (FAT4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to FAT Tumor Suppressor Homolog 4 (FAT4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for FAT Tumor Suppressor Homolog 4 (FAT4) CLIA Kit Customized Service Offer
n/a ELISA Kit for FAT Tumor Suppressor Homolog 4 (FAT4) ELISA Kit Customized Service Offer
  1. "Identification of new human cadherin genes using a combination of protein motif search and gene finding methods."J. Mol. Biol. 337:307-317(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma."Cancer Lett. 197:63-68(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Comparative integromics on FAT1, FAT2, FAT3 and FAT4."Int. J. Mol. Med. 18:523-528(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Mutations in genes encoding the cadherin receptor-ligand pair DCHS1 and FAT4 disrupt cerebral cortical development." Nat. Genet. 45:1300-1308(2013) [PubMed] [Europe PMC] [Abstract]
  8. "Hennekam syndrome can be caused by FAT4 mutations and be allelic to Van Maldergem syndrome."Hum. Genet. 133:1161-1167(2014) [PubMed] [Europe PMC] [Abstract]