THAP Domain Containing Protein 9 (THAP9)

The THAP domain includes a C2CH signature, an AVPTIF box, and several other conserved amino acids. It appears to be restricted to animal proteins and shows similarity to a DNA-binding domain of Drosophila P element transposase.

By searching databases, Roussigne et al. (2003) identified several proteins containing an N-terminal THAP domain, including THAP9. The THAP domain of the deduced 903-amino acid THAP9 protein includes a C2CH signature, an AVPTIF box, and several other conserved amino acids. The THAP domain is followed by a stretch that shares similarity with the Drosophila P element transposase.Hartz (2009) mapped the THAP9 gene to chromosome 4q21.22 based on an alignment of the THAP9 sequence with the genomic sequence.