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Replication Timing Regulatory Factor 1 (RIF1)

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RAP1 Interacting Factor Homolog; Telomere-associated protein RIF1

Replication Timing Regulatory Factor 1 (RIF1)
CCC N452
HGNC 23207
MGI 1098622
PubMed 22850673
RGD 1562474
UniProt Q5UIP0
Wiki RIF1
RIF1 contains 2,472 amino acids. Alignment of the human, mouse, and fugu proteins revealed 2 conserved N-terminal regions and a conserved C-terminal region. The first 340 amino acids contain 8 armadillo-type repeats, which are helical folds that typically occur in long arrays, creating an extended curved protein or RNA interaction surface. RIF1 also contains a central serine-rich region and a bipartite nuclear localization signal within the C-terminal conserved region.After induction of double-strand breaks in ALT cells, RIF1 formed foci that colocalized with other DNA damage response factors. This response was strictly dependent on ATM and 53BP1, but was not affected by diminished function of ATR, BRCA1, CHK2, NBS1, or MRE11. RIF1 inhibition resulted in radiosensitivity and a defect in the intra-S-phase checkpoint.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Replication Timing Regulatory Factor 1 (RIF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Replication Timing Regulatory Factor 1 (RIF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Replication Timing Regulatory Factor 1 (RIF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Replication Timing Regulatory Factor 1 (RIF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Replication Timing Regulatory Factor 1 (RIF1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Replication Timing Regulatory Factor 1 (RIF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Replication Timing Regulatory Factor 1 (RIF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Replication Timing Regulatory Factor 1 (RIF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Replication Timing Regulatory Factor 1 (RIF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Replication Timing Regulatory Factor 1 (RIF1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Replication Timing Regulatory Factor 1 (RIF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Replication Timing Regulatory Factor 1 (RIF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Replication Timing Regulatory Factor 1 (RIF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Replication Timing Regulatory Factor 1 (RIF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Replication Timing Regulatory Factor 1 (RIF1) ELISA Kit Customized Service Offer
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