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Phosphoribosyl Transferase Domain Containing Protein 1 (PRTFDC1)

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HHGP

Phosphoribosyl Transferase Domain Containing Protein 1 (PRTFDC1)
CCC N434
HGNC 23333
PubMed 21054786
UniProt Q9NRG1
The predicted PRTFDC1 protein contains a phosphoribosyl transferase domain, but it lacks conservation of 11 HPRT1 residues critical for HPRT function, suggesting that PRTFDC1 has lost its ancestral HPRT activity. Database analysis revealed that Prtfdc1 is present in several vertebrate species. However, in mouse, the Prtfdc1 gene appeared to be inactive due to 3 independent mutations.
PRTFDC1was inactivated either by deletion or hypermethylation in a significant subset of oral squamous cell carcinomas. Restoration of PRTFDC1 expression in 1 of these lines inhibited cell growth in colony formation assays, whereas knockdown of PRTFDC1 expression in PRTFDC1-expressing cells promoted cell growth.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphoribosyl Transferase Domain Containing Protein 1 (PRTFDC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphoribosyl Transferase Domain Containing Protein 1 (PRTFDC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphoribosyl Transferase Domain Containing Protein 1 (PRTFDC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphoribosyl Transferase Domain Containing Protein 1 (PRTFDC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphoribosyl Transferase Domain Containing Protein 1 (PRTFDC1) ELISA Kit Customized Service Offer
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