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Membrane Associated Ring Finger Protein 8 (MARCH8)

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MIR; c-MIR; MARCH-VIII; RNF178; Cellular Modulator Of Immune Recognition; E3 ubiquitin-protein ligase MARCH8; RING finger protein 178; Cellular modulator of immune recognition

Membrane Associated Ring Finger Protein 8 (MARCH8)
CCC N431
HGNC 23356
MGI 1919029
PubMed 22904187
RGD 1309339
UniProt Q5T0T0
MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH8 induces the internalization of several membrane glycoproteins.
The deduced 291-amino acid protein has an N-terminal BKS-PHD domain, followed by 2 transmembrane domains. Both the N and C termini were predicted to be cytoplasmic. RT-PCR analysis detected MIR expression in neonatal brain and in adult lymph node, spleen, and placenta, but not in other tissues examined. It was also detected in monocytes and immature dendritic cells, but not in lymphocytes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Membrane Associated Ring Finger Protein 8 (MARCH8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Membrane Associated Ring Finger Protein 8 (MARCH8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Membrane Associated Ring Finger Protein 8 (MARCH8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Membrane Associated Ring Finger Protein 8 (MARCH8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Membrane Associated Ring Finger Protein 8 (MARCH8) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Membrane Associated Ring Finger Protein 8 (MARCH8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Membrane Associated Ring Finger Protein 8 (MARCH8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Membrane Associated Ring Finger Protein 8 (MARCH8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Membrane Associated Ring Finger Protein 8 (MARCH8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Membrane Associated Ring Finger Protein 8 (MARCH8) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Membrane Associated Ring Finger Protein 8 (MARCH8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Membrane Associated Ring Finger Protein 8 (MARCH8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Membrane Associated Ring Finger Protein 8 (MARCH8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Membrane Associated Ring Finger Protein 8 (MARCH8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Membrane Associated Ring Finger Protein 8 (MARCH8) ELISA Kit Customized Service Offer
  1. "c-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and MIR2 and has similar activity."J. Biol. Chem. 278:14657-14668(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins."J. Virol. 78:1109-1120(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Interleukin-10-induced MARCH1 mediates intracellular sequestration of MHC class II in monocytes."Eur. J. Immunol. 38:1225-1230(2008) [PubMed] [Europe PMC] [Abstract]
  7. "The HLA-DRalpha chain is modified by polyubiquitination."J. Biol. Chem. 284:7007-7016(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Sorting of MHC class II molecules into exosomes through a ubiquitin-independent pathway."Traffic 10:1518-1527(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Solution structure of the RING domain of the human cellular modulator of immune recognition protein."Submitted (JUN-2006) to the PDB data bank