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Signal Peptidase Complex Subunit 1 Homolog (SPCS1)

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SPC12; SPC1; Microsomal signal peptidase 12 kDa subunit

Signal Peptidase Complex Subunit 1 Homolog (SPCS1)
CCC N427
HGNC 23401
MGI 1916269
PubMed 24009510
UniProt Q9Y6A9
By RT-PCR of a human fetal brain cDNA library using degenerate oligonucleotides based on canine Spcs1, Kailes and Hartmann (1996) cloned human SPCS1.
The 102-amino acid protein has a predicted molecular mass of 11.8 kD. SPCS1 shows no sequence similarity to any of the other signal peptidase complex subunits.
SPCS1 contains 2 predicted transmembrane domains, and immunoblot analysis of protease-digested canine microsomes showed that both the N- and C-terminal domains of Spcs1 and Spcs2 are cytoplasmic.The International Radiation Hybrid Mapping Consortium mapped the SPCS1 gene to chromosome 3 .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Signal Peptidase Complex Subunit 1 Homolog (SPCS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Signal Peptidase Complex Subunit 1 Homolog (SPCS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Signal Peptidase Complex Subunit 1 Homolog (SPCS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Signal Peptidase Complex Subunit 1 Homolog (SPCS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Signal Peptidase Complex Subunit 1 Homolog (SPCS1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Signal Peptidase Complex Subunit 1 Homolog (SPCS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Signal Peptidase Complex Subunit 1 Homolog (SPCS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Signal Peptidase Complex Subunit 1 Homolog (SPCS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Signal Peptidase Complex Subunit 1 Homolog (SPCS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Signal Peptidase Complex Subunit 1 Homolog (SPCS1) ELISA Kit Customized Service Offer
  1. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Membrane topology of the 12- and the 25-kDa subunits of the mammalian signal peptidase complex."J. Biol. Chem. 271:3925-3929(1996) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "Large-scale top down proteomics of the human proteome: membrane proteins, mitochondria, and senescence."Mol. Cell. Proteomics 12:3465-3473(2013) [PubMed] [Europe PMC] [Abstract]