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Post GPI Attachment To Proteins 3 (PGAP3)

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PERLD1; CAB2; PER1; Per1-Like Domain Containing 1; COS16 homolog; Gene coamplified with ERBB2 protein

Post GPI Attachment To Proteins 3 (PGAP3)
CCC N396
HGNC 23719
MGI 2444461
PubMed 24439110
UniProt Q96FM1
The deduced 319-amino acid protein contains several transmembrane domains. CAB2 was ubiquitously expressed, with highest levels in adult thyroid and placenta and in all 4 fetal tissues examined. Fluorescence-tagged CAB2 accumulated in cytoplasmic vesicles in a transfected human breast cancer cell line.
The human and mouse MGC9753 proteins contain 320 amino acids and share 85% amino acid identity. Both have an N-terminal signal peptide, followed by an extracellular 6-cysteine domain, 7 transmembrane domains, and an N-glycosylation site at asn40. Human MGC9753 shares 90.6% identity with the CAB2 protein reported by Nezu et al. (2002), which diverges in the central region and lacks transmembrane domain-3 due to a frameshift.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Post GPI Attachment To Proteins 3 (PGAP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Post GPI Attachment To Proteins 3 (PGAP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Post GPI Attachment To Proteins 3 (PGAP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Post GPI Attachment To Proteins 3 (PGAP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Post GPI Attachment To Proteins 3 (PGAP3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Post GPI Attachment To Proteins 3 (PGAP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Post GPI Attachment To Proteins 3 (PGAP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Post GPI Attachment To Proteins 3 (PGAP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Post GPI Attachment To Proteins 3 (PGAP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Post GPI Attachment To Proteins 3 (PGAP3) ELISA Kit Customized Service Offer
  1. "Identification of the CAB2/hCOS16 gene required for the repair of DNA double-strand breaks on a core amplified region of the 17q12 locus in breast and gastric cancers."Jpn. J. Cancer Res. 93:1183-1186(2002) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "MGC9753 gene, located within PPP1R1B-STARD3-ERBB2-GRB7 amplicon on human chromosome 17q12, encodes the seven-transmembrane receptor with extracellular six-cysteine domain."Int. J. Oncol. 22:1369-1374(2003) [PubMed] [Europe PMC] [Abstract]
  8. "PER1 is required for GPI-phospholipase A2 activity and involved in lipid remodeling of GPI-anchored proteins."Mol. Biol. Cell 17:5253-5264(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Mutations in PGAP3 impair GPI-anchor maturation, causing a subtype of hyperphosphatasia with mental retardation." Am. J. Hum. Genet. 94:278-287(2014) [PubMed] [Europe PMC] [Abstract]