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Zinc Finger Antiviral Protein (ZAP)

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ZC3HAV1; ZC3HDC2; ZC3H2; PARP13; ARTD13; Zinc Finger CCCH-Type,Antiviral 1; CCCH-Type Zinc Finger Antiviral Protein; ADP-ribosyltransferase diphtheria toxin-like 13

Zinc Finger Antiviral Protein (ZAP)
CCC N394
HGNC 23721
MGI 1926031
PubMed 21876179
RGD 628694
UniProt Q7Z2W4
ZC3HAV1 is a CCCH-type zinc finger protein that prevents infection by retroviruses.PARP12 and ZCH3HAV1 share 27.5% and 26% overall amino acid sequence identity with TIPARP, respectively. They stated that the deduced ZC3HAV1 protein contains 902 amino acids.
Two mRNAs (3.5 and 4.5 kb) were observed in most tissues, possibly corresponding to alternative splice variants. Expression of the gene caused profound and specific loss of viral mRNAs from the cytoplasm of rat and mouse cells without affecting the levels of nuclear mRNAs. This observation suggested the existence of a previously unknown machinery for the inhibition of virus replication, targeting a step in viral gene expression.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger Antiviral Protein (ZAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger Antiviral Protein (ZAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger Antiviral Protein (ZAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger Antiviral Protein (ZAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger Antiviral Protein (ZAP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger Antiviral Protein (ZAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger Antiviral Protein (ZAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger Antiviral Protein (ZAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger Antiviral Protein (ZAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger Antiviral Protein (ZAP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger Antiviral Protein (ZAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger Antiviral Protein (ZAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger Antiviral Protein (ZAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger Antiviral Protein (ZAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger Antiviral Protein (ZAP) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Positive selection and increased antiviral activity associated with the PARP-containing isoform of human zinc-finger antiviral protein."PLoS Genet. 4:E21-E21(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "ZAP-mediated mRNA degradation."RNA Biol. 5:65-67(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Expression and RNA-binding of human zinc-finger antiviral protein."Biochem. Biophys. Res. Commun. 396:696-702(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Identification of a dominant negative inhibitor of human zinc finger antiviral protein reveals a functional endogenous pool and critical homotypic interactions."J. Virol. 84:4504-4512(2010) [PubMed] [Europe PMC] [Abstract]
  17. "DEXH-Box protein DHX30 is required for optimal function of the zinc-finger antiviral protein."Protein Cell 1:956-964(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  19. "Toward a unified nomenclature for mammalian ADP-ribosyltransferases."Trends Biochem. Sci. 35:208-219(2010) [PubMed] [Europe PMC] [Abstract]
  20. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  21. "ZAPS electrifies RIG-I signaling."Nat. Immunol. 12:11-12(2011) [PubMed] [Europe PMC] [Abstract]
  22. "ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses."Nat. Immunol. 12:37-44(2011) [PubMed] [Europe PMC] [Abstract]
  23. "Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation."Proc. Natl. Acad. Sci. U.S.A. 108:15834-15839(2011) [PubMed] [Europe PMC] [Abstract]
  24. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  25. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  26. "Zinc-finger antiviral protein inhibits XMRV infection."PLoS ONE 7:E39159-E39159(2012) [PubMed] [Europe PMC] [Abstract]
  27. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]