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Signal Induced Proliferation Associated 1 Like Protein 2 (SIPA1L2)

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SPAL2

Signal Induced Proliferation Associated 1 Like Protein 2 (SIPA1L2)
CCC N387
HGNC 23800
MGI 2676970
PubMed 16710414
RGD 1306269
UniProt Q9P2F8
Wiki SIPA1L2
SIPA1 exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region.
By sequencing clones obtained from a size-fractionated adult brain cDNA library, Nagase et al. (2000) cloned SIPA1L2, which they designated KIAA1389. The deduced 1,514-amino acid protein shares significant similarity with SIPA1L1. RT-PCR ELISA detected moderate expression in all adult and fetal tissues and specific adult brain regions examined.The International Radiation Hybrid Mapping Consortium mapped the SIPA1L2 gene to chromosome 1 .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Signal Induced Proliferation Associated 1 Like Protein 2 (SIPA1L2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Signal Induced Proliferation Associated 1 Like Protein 2 (SIPA1L2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Signal Induced Proliferation Associated 1 Like Protein 2 (SIPA1L2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Signal Induced Proliferation Associated 1 Like Protein 2 (SIPA1L2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Signal Induced Proliferation Associated 1 Like Protein 2 (SIPA1L2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Signal Induced Proliferation Associated 1 Like Protein 2 (SIPA1L2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Signal Induced Proliferation Associated 1 Like Protein 2 (SIPA1L2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Signal Induced Proliferation Associated 1 Like Protein 2 (SIPA1L2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Signal Induced Proliferation Associated 1 Like Protein 2 (SIPA1L2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Signal Induced Proliferation Associated 1 Like Protein 2 (SIPA1L2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Signal Induced Proliferation Associated 1 Like Protein 2 (SIPA1L2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Signal Induced Proliferation Associated 1 Like Protein 2 (SIPA1L2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Signal Induced Proliferation Associated 1 Like Protein 2 (SIPA1L2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Signal Induced Proliferation Associated 1 Like Protein 2 (SIPA1L2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Signal Induced Proliferation Associated 1 Like Protein 2 (SIPA1L2) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]