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E2F Transcription Factor 7 (E2F7)

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E2F Transcription Factor 7 (E2F7)
CCC N384
HGNC 23820
MGI 1289147
PubMed 12893818
RGD 1310258
UniProt Q96AV8
Wiki E2F7
Ectopic expression of E2F7 in U2OS cells suppressed E2F target genes and led to an accumulation of cells in G1. E2F7 associated with E2F-regulated promoters in vivo, and this association increased in S phase. Chromatin immunoprecipitation (ChIP) assays showed that E2F7 bound the promoters of a subset of E2F-dependent genes, including E2F1 and CDC6 (CDC18L), in U2OS cells and human fibroblasts. Inhibition of E2F7 expression resulted in specific derepression of the E2F1 and CDC6 promoters.E2F7A lacks exon 12 and encodes a 728-amino acid protein, whereas E2F7B includes exon 12 and encodes a 911-amino acid protein. The E2F7A and E2F7B proteins differ only after amino acid 713, and both have 2 N-terminal E2F-type DNA-binding domains containing highly conserved residues involved in binding.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant E2F Transcription Factor 7 (E2F7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to E2F Transcription Factor 7 (E2F7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to E2F Transcription Factor 7 (E2F7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for E2F Transcription Factor 7 (E2F7) CLIA Kit Customized Service Offer
n/a ELISA Kit for E2F Transcription Factor 7 (E2F7) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant E2F Transcription Factor 7 (E2F7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to E2F Transcription Factor 7 (E2F7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to E2F Transcription Factor 7 (E2F7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for E2F Transcription Factor 7 (E2F7) CLIA Kit Customized Service Offer
n/a ELISA Kit for E2F Transcription Factor 7 (E2F7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant E2F Transcription Factor 7 (E2F7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to E2F Transcription Factor 7 (E2F7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to E2F Transcription Factor 7 (E2F7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for E2F Transcription Factor 7 (E2F7) CLIA Kit Customized Service Offer
n/a ELISA Kit for E2F Transcription Factor 7 (E2F7) ELISA Kit Customized Service Offer
  1. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes."EMBO J. 22:6289-6298(2003) [PubMed] [Europe PMC] [Abstract]
  5. "E2F-7: a distinctive E2F family member with an unusual organization of DNA-binding domains."Oncogene 23:5138-5150(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development."Dev. Cell 14:62-75(2008) [PubMed] [Europe PMC] [Abstract]
  7. "DNA-damage response control of E2F7 and E2F8."EMBO Rep. 9:252-259(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1."EMBO J. 31:3871-3884(2012) [PubMed] [Europe PMC] [Abstract]
  11. "E2F7 can regulate proliferation, differentiation, and apoptotic responses in human keratinocytes: implications for cutaneous squamous cell carcinoma formation."Cancer Res. 69:1800-1808(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Loss of E2F7 expression is an early event in squamous differentiation and causes derepression of the key differentiation activator Sp1."J. Invest. Dermatol. 131:1077-1084(2011) [PubMed] [Europe PMC] [Abstract]
  13. "E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression."Genes Dev. 26:1533-1545(2012) [PubMed] [Europe PMC] [Abstract]
  14. "The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence."Genes Dev. 26:1546-1557(2012) [PubMed] [Europe PMC] [Abstract]