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BTB/POZ Domain Containing Protein 12 (BTBD12)

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Structure-specific endonuclease subunit SLX4

BTB/POZ Domain Containing Protein 12 (BTBD12)
CCC N382
HGNC 23845
MGI 106299
PubMed 19595722
RGD 1566009
UniProt Q8IY92
BTBD12 functions as a critical scaffold element for the assembly of a multiprotein complex containing enzymes involved in DNA maintenance and repair.Similar complexes were detected in other human cell lines examined. Domain analysis showed that MSH2-MSH3, ERCC4-ERCC1, and C20ORF94 associated with the N-terminal region of SLX4, while TERF2-TERF2IP, MUS81-EME1, and PLK1 bound the C-terminal region of SLX4. SLX1 associated with the extreme C terminus of SLX4. The SLX4 complex was recruited to sites of DNA damage and repaired 3-prime flap, 5-prime flap, and replication fork structures, consistent with the activities of the SLX4-associated DNA repair factors. The SLX1-SLX4 module specifically promoted symmetrical cleavage of static and migrating Holliday junctions.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant BTB/POZ Domain Containing Protein 12 (BTBD12) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to BTB/POZ Domain Containing Protein 12 (BTBD12) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to BTB/POZ Domain Containing Protein 12 (BTBD12) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for BTB/POZ Domain Containing Protein 12 (BTBD12) CLIA Kit Customized Service Offer
n/a ELISA Kit for BTB/POZ Domain Containing Protein 12 (BTBD12) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant BTB/POZ Domain Containing Protein 12 (BTBD12) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to BTB/POZ Domain Containing Protein 12 (BTBD12) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to BTB/POZ Domain Containing Protein 12 (BTBD12) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for BTB/POZ Domain Containing Protein 12 (BTBD12) CLIA Kit Customized Service Offer
n/a ELISA Kit for BTB/POZ Domain Containing Protein 12 (BTBD12) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant BTB/POZ Domain Containing Protein 12 (BTBD12) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to BTB/POZ Domain Containing Protein 12 (BTBD12) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to BTB/POZ Domain Containing Protein 12 (BTBD12) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for BTB/POZ Domain Containing Protein 12 (BTBD12) CLIA Kit Customized Service Offer
n/a ELISA Kit for BTB/POZ Domain Containing Protein 12 (BTBD12) ELISA Kit Customized Service Offer
  1. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair."Cell 138:63-77(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases."Cell 138:78-89(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair."Mol. Cell 35:116-127(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Drosophila MUS312 and the vertebrate ortholog BTBD12 interact with DNA structure-specific endonucleases in DNA repair and recombination."Mol. Cell 35:128-135(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype."Nat. Genet. 43:138-141(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Mutations of the SLX4 gene in Fanconi anemia."Nat. Genet. 43:142-146(2011) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Analysis of the novel Fanconi anemia gene SLX4/FANCP in familial breast cancer cases."Hum. Mutat. 34:70-73(2013) [PubMed] [Europe PMC] [Abstract]