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BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3)

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C6.1A; BRCC36; C6.1A; CXorf53; Lys-63-specific deubiquitinase BRCC36; BRCA1-A complex subunit BRCC36; BRISC complex subunit BRCC36

BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3)
CCC N348
HGNC 24185
MGI 2389572
PubMed 1303175
RGD 1588543
UniProt P46736
Wiki BRCC3
BRCC3 encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This protein is also thought to be involved in the cellular response to ionizing radiation and progression through the G2/M checkpoint. Alternative splicing results in multiple transcript variants.
The complex showed UBC5-dependent ubiquitin E3 ligase activity. Inclusion of BRE and BRCC3 enhanced ubiquitination by the complex, and cancer-associated truncations in BRCA1 reduced the association of BRE and BRCC3 with the complex. RNA interference of BRE and BRCC3 in HeLa cells increased cell sensitivity to ionizing radiation and resulted in a defect in G2/M checkpoint arrest. the BRCC is a ubiquitin E3 ligase that enhances cellular survival following DNA damage.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPN348Hu01 Recombinant BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAN348Hu01 Polyclonal Antibody to BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) WB; IHC; ICC; IP.
MAN348Hu21 Monoclonal Antibody to BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) WB; IHC; ICC; IP.
Assay Kits SEN348Hu ELISA Kit for BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for BRCA1/BRCA2 Containing Complex Subunit 3 (BRCC3) ELISA Kit Customized Service Offer
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  3. "Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair."Mol. Cell 12:1087-1099(2003) [PubMed] [Europe PMC] [Abstract]
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