Glycerate Kinase (GLYCTK)

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HBEBP4; HBEBP2; HBeAg-binding protein 4

Glycerate Kinase (GLYCTK)
Glycerate kinase activity was less than 5% of normal, whereas D-glycerate dehydrogenase (glyoxylate reductase) and triokinase activities were normal. The longer variant, GLYCTK1, encodes a deduced 523-amino acid protein. The shorter variant, GLYCTK2, which lacks exon 4, encodes a deduced 234-amino acid protein. PCR analysis of 17 human tissues detected variable levels of both transcripts in all tissues examined. In situ hybridization of adult mouse tissues showed Glyctk in several specific brain regions, in renal cortex interstitial cells, in epithelium of the interlobular bile duct, and in skeletal muscle. Fluorescence-tagged GLYCTK1 and GLYCTK2 were localized in cytoplasmic particles in transfected COS-7 cells. GLYCTK2, but not GLYCTK1, localized in mitochondria.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glycerate Kinase (GLYCTK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glycerate Kinase (GLYCTK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glycerate Kinase (GLYCTK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glycerate Kinase (GLYCTK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glycerate Kinase (GLYCTK) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glycerate Kinase (GLYCTK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glycerate Kinase (GLYCTK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glycerate Kinase (GLYCTK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glycerate Kinase (GLYCTK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glycerate Kinase (GLYCTK) ELISA Kit Customized Service Offer
  1. "Isolation and characterization of the human D-glyceric acidemia related glycerate kinase gene GLYCTK1 and its alternatively splicing variant GLYCTK2."DNA Seq. 17:1-7(2006) [PubMed] [Europe PMC] [Abstract]
  2. "Large-scale cDNA transfection screening for genes related to cancer development and progression." Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "D-glyceric aciduria is caused by genetic deficiency of D-glycerate kinase (GLYCTK)."Hum. Mutat. 31:1280-1285(2010) [PubMed] [Europe PMC] [Abstract]
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]