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NMD3 Homolog (NMD3)

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CGI-07; 60S ribosomal export protein NMD3

NMD3 Homolog (NMD3)
CCC N338
HGNC 24250
MGI 2140103
PubMed 20584915
UniProt Q96D46
Wiki NMD3
Treatment of transfected HeLa cells with leptomycin B, an inhibitor of CRM1-mediated nuclear export, strongly increased accumulation of NMD3 in nuclei and nucleoli, suggesting that NMD3 shuttles between the cytoplasm and nucleus in a CRM1-dependent manner.
Mutant forms of NMD3 containing substitutions in the NES domain showed reduced export to the cytoplasm in Xenopus oocytes. Depletion of the nuclear RAN-GTP pool also reduced export of NMD3 to the cytoplasm, indicating that NMD3 export is RAN-GTP dependent. NMD3 associated with 60S subunits in both nuclear and cytoplasmic extracts of Xenopus oocytes, but not with 40S or 80S subunits. NES-defective NMD3 mutants acted as dominant-negative inhibitors of 60S subunit export.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NMD3 Homolog (NMD3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NMD3 Homolog (NMD3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NMD3 Homolog (NMD3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NMD3 Homolog (NMD3) CLIA Kit Customized Service Offer
n/a ELISA Kit for NMD3 Homolog (NMD3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NMD3 Homolog (NMD3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NMD3 Homolog (NMD3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NMD3 Homolog (NMD3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NMD3 Homolog (NMD3) CLIA Kit Customized Service Offer
n/a ELISA Kit for NMD3 Homolog (NMD3) ELISA Kit Customized Service Offer
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