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TP53RK Binding Protein (TPRKB)

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CGI-121; PRPK-binding protein; EKC/KEOPS complex subunit TPRKB

TP53RK Binding Protein (TPRKB)
CCC N336
HGNC 24259
MGI 1917036
RGD 1309786
UniProt Q9Y3C4
The deduced 175-amino acid protein has a calculated molecular mass of 19.7 kD.CGI-121 shares 85% amino acid identity with mouse Cgi-121 and 34% amino acid identity with the yeast homolog. CGI-121-L1 encodes a deduced 214-amino acid protein with a calculated molecular mass of 23.9 kD, and CGI-121-S1 encodes a deduced 142-amino acid protein with a calculated molecular mass of 16.1 kD.Western blot analysis detected a single CGI-121 protein with an apparent molecular mass of 20 kD. Immunofluorescent microscopy detected endogenous CGI-121 distributed in both the nucleus and the cytosol.Neither CGI-121 nor PRPK formed homodimers in vivo or in vitro. Coprecipitation of p53 with PRPK was inhibited by adding recombinant CGI-121 in vitro, suggesting that CGI-121 may inhibit the PRPK-p53 interaction

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TP53RK Binding Protein (TPRKB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TP53RK Binding Protein (TPRKB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TP53RK Binding Protein (TPRKB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TP53RK Binding Protein (TPRKB) CLIA Kit Customized Service Offer
n/a ELISA Kit for TP53RK Binding Protein (TPRKB) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TP53RK Binding Protein (TPRKB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TP53RK Binding Protein (TPRKB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TP53RK Binding Protein (TPRKB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TP53RK Binding Protein (TPRKB) CLIA Kit Customized Service Offer
n/a ELISA Kit for TP53RK Binding Protein (TPRKB) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TP53RK Binding Protein (TPRKB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TP53RK Binding Protein (TPRKB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TP53RK Binding Protein (TPRKB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TP53RK Binding Protein (TPRKB) CLIA Kit Customized Service Offer
n/a ELISA Kit for TP53RK Binding Protein (TPRKB) ELISA Kit Customized Service Offer
  1. "Identification of CGI-121, a novel PRPK (p53-related protein kinase)-binding protein."Biochem. Biophys. Res. Commun. 303:399-405(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "The human EKC/KEOPS complex is recruited to Cullin2 ubiquitin ligases by the human tumour antigen PRAME."PLoS ONE 7:E42822-E42822(2012) [PubMed] [Europe PMC] [Abstract]
  7. "Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine."Mol. Cell 32:259-275(2008) [PubMed] [Europe PMC] [Abstract]