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Family With Sequence Similarity 175, Member A (FAM175A)

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CCDC98; ABRA1; Abraxas Protein; Coiled-Coil Domain Containing 98; BRCA1-A complex subunit Abraxas

Family With Sequence Similarity 175, Member A (FAM175A)
CCC N321
HGNC 25829
MGI 1917931
PubMed 22357538
RGD 1305287
UniProt Q6UWZ7
The 409-amino acid ABRA1 protein contains an ABR domain and a coiled-coil domain followed by the phospho-ser-X-X-phe motif at the C-terminal end of the protein. ABRA1 shares 39% amino acid identity in the N-terminal region with ABRO1, which also contains an ABR domain and a coiled-coil domain.Abraxas binds BRCA1 to the mutual exclusion of BACH1 and CTIP, forming a third type of BRCA1 complex. Abraxas recruits the ubiquitin-interacting motif (UIM)-containing protein RAP80 to BRCA1. Both Abraxas and RAP80 were required for DNA damage resistance, G2/M checkpoint control, and DNA repair. RAP80 was required for optimal accumulation of BRCA1 on damaged DNA (foci) in response to ionizing radiation, and the UIM domains alone were capable of foci formation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Family With Sequence Similarity 175, Member A (FAM175A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Family With Sequence Similarity 175, Member A (FAM175A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Family With Sequence Similarity 175, Member A (FAM175A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Family With Sequence Similarity 175, Member A (FAM175A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Family With Sequence Similarity 175, Member A (FAM175A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Family With Sequence Similarity 175, Member A (FAM175A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Family With Sequence Similarity 175, Member A (FAM175A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Family With Sequence Similarity 175, Member A (FAM175A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Family With Sequence Similarity 175, Member A (FAM175A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Family With Sequence Similarity 175, Member A (FAM175A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Family With Sequence Similarity 175, Member A (FAM175A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Family With Sequence Similarity 175, Member A (FAM175A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Family With Sequence Similarity 175, Member A (FAM175A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Family With Sequence Similarity 175, Member A (FAM175A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Family With Sequence Similarity 175, Member A (FAM175A) ELISA Kit Customized Service Offer
  1. "Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response."Science 316:1194-1198(2007) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "CCDC98 targets BRCA1 to DNA damage sites."Nat. Struct. Mol. Biol. 14:716-720(2007) [PubMed] [Europe PMC] [Abstract]
  6. "CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response."Nat. Struct. Mol. Biol. 14:710-715(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage."Proc. Natl. Acad. Sci. U.S.A. 104:20759-20763(2007) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks."Genes Dev. 23:740-754(2009) [PubMed] [Europe PMC] [Abstract]
  11. "NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control."Genes Dev. 23:729-739(2009) [PubMed] [Europe PMC] [Abstract]
  12. "MERIT40 facilitates BRCA1 localization and DNA damage repair."Genes Dev. 23:719-728(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Analysis of the genes coding for the BRCA1-interacting proteins, RAP80 and Abraxas (CCDC98), in high-risk, non-BRCA1/2, multiethnic breast cancer cases."Breast Cancer Res. Treat. 117:453-459(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Breast cancer-associated Abraxas mutation disrupts nuclear localization and DNA damage response functions."Sci. Transl. Med. 4:122ra23-122ra23(2012) [PubMed] [Europe PMC] [Abstract]
  18. "Mislocalization of BRCA1-complex due to ABRAXAS Arg361Gln mutation."J. Biomol. Struct. Dyn. 2014:1-11(2014) [PubMed] [Europe PMC] [Abstract]