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Jumonji Domain Containing Protein 5 (JMJD5)

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KDM8; Lysine-specific demethylase 8

Jumonji Domain Containing Protein 5 (JMJD5)
CCC N320
HGNC 25840
MGI 1924285
PubMed 22375008
RGD 1304823
UniProt Q8N371
JMJD5 is a putative histone lysine demethylase that contains a Jumonji C (JmjC) domain. Using insertional mutagenesis with Blm (RECQL3)-deficient mice, Suzuki et al. (2006) identified Jmjd5 as a putative tumor suppressor. Jmjd5 knockdown by RNA interference increased the mutation rate in mouse fibroblasts and increased their tolerance to the DNA methylating agent MNNG, suggesting that Jmjd5 may function in DNA mismatch repair.
Hartz (2008) mapped the JMJD5 gene to chromosome 16p12.1 based on an alignment of the JMJD5 sequence with the genomic sequence (build 36.1).

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Jumonji Domain Containing Protein 5 (JMJD5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Jumonji Domain Containing Protein 5 (JMJD5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Jumonji Domain Containing Protein 5 (JMJD5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Jumonji Domain Containing Protein 5 (JMJD5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Jumonji Domain Containing Protein 5 (JMJD5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Jumonji Domain Containing Protein 5 (JMJD5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Jumonji Domain Containing Protein 5 (JMJD5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Jumonji Domain Containing Protein 5 (JMJD5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Jumonji Domain Containing Protein 5 (JMJD5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Jumonji Domain Containing Protein 5 (JMJD5) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "KDM8, a H3K36me2 histone demethylase that acts in the cyclin A1 coding region to regulate cancer cell proliferation."Proc. Natl. Acad. Sci. U.S.A. 107:9671-9676(2010) [PubMed] [Europe PMC] [Abstract]