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GINS Complex Subunit 3 (GINS3)

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PSF3; DNA replication complex GINS protein PSF3

GINS Complex Subunit 3 (GINS3)
CCC N318
HGNC 25851
MGI 1926083
RGD 1308153
UniProt Q9BRX5
The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4), Psf1 (GINS1), Psf2 (GINS2), and Psf3. The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts. By searching a human database for sequences similar to yeast Psf3, Takayama et al. (2003) identified GINS3, which they called PSF3. The deduced protein contains 216 amino acids.The International Radiation Hybrid Mapping Consortium mapped the GINS3 gene to chromosome 16.
The GINS complex derives its name from the Japanese words Go, Ichi, Nii, and San, which mean 5, 1, 2, and 3, respectively, and refer to the numbering of the yeast homologs of the GINS complex.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GINS Complex Subunit 3 (GINS3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GINS Complex Subunit 3 (GINS3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GINS Complex Subunit 3 (GINS3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GINS Complex Subunit 3 (GINS3) CLIA Kit Customized Service Offer
n/a ELISA Kit for GINS Complex Subunit 3 (GINS3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GINS Complex Subunit 3 (GINS3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GINS Complex Subunit 3 (GINS3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GINS Complex Subunit 3 (GINS3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GINS Complex Subunit 3 (GINS3) CLIA Kit Customized Service Offer
n/a ELISA Kit for GINS Complex Subunit 3 (GINS3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GINS Complex Subunit 3 (GINS3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GINS Complex Subunit 3 (GINS3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GINS Complex Subunit 3 (GINS3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GINS Complex Subunit 3 (GINS3) CLIA Kit Customized Service Offer
n/a ELISA Kit for GINS Complex Subunit 3 (GINS3) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The human GINS complex binds to and specifically stimulates human DNA polymerase alpha-primase."EMBO Rep. 8:99-103(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Molecular architecture of the human GINS complex."EMBO Rep. 8:678-684(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Crystal structure of the human GINS complex."Genes Dev. 21:1316-1321(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Structure of the human GINS complex and its assembly and functional interface in replication initiation."Nat. Struct. Mol. Biol. 14:388-396(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Crystal structure of the GINS complex and functional insights into its role in DNA replication."Proc. Natl. Acad. Sci. U.S.A. 104:12685-12690(2007) [PubMed] [Europe PMC] [Abstract]