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C-Myc Promoter Binding Protein (MYCPBP)

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DENND4A; IRLB; DENN/MADD Domain Containing 4A; CMyc Promoter

C-Myc Promoter Binding Protein (MYCPBP)
CCC N312
HGNC 24321
MGI 2142979
PubMed 8056341
UniProt Q7Z401
Wiki DENND4A

Stasiv et al. (1994) reported the cloning of a cDNA encoding a c-myc promoter-binding protein called IRLB. The predicted amino acid sequence contains a putative alpha-helical DNA binding region. Bacterially expressed protein was shown to bind to the ISRE (interferon-stimulated response element) of the c-myc promoter.

Myc (c-Myc) codes for a protein that binds to the DNA of other genes and is therefore a transcription factor. When a gene like Myc is altered to cause cancer, the cancerous version of the gene is called an oncogene. The healthy version of the gene that it is derived from is called a proto-oncogene.A mutated version of Myc is found in many cancers which causes Myc to be persistently expressed.Myc protein belongs to Myc family of transcription factors, which also includes N-Myc and L-Myc genes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant C-Myc Promoter Binding Protein (MYCPBP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to C-Myc Promoter Binding Protein (MYCPBP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to C-Myc Promoter Binding Protein (MYCPBP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for C-Myc Promoter Binding Protein (MYCPBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for C-Myc Promoter Binding Protein (MYCPBP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant C-Myc Promoter Binding Protein (MYCPBP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to C-Myc Promoter Binding Protein (MYCPBP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to C-Myc Promoter Binding Protein (MYCPBP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for C-Myc Promoter Binding Protein (MYCPBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for C-Myc Promoter Binding Protein (MYCPBP) ELISA Kit Customized Service Offer
  1. "Molecular cloning, structural analysis, and expression of a human IRLB, MYC promoter-binding protein: new DENN domain-containing protein family emerges."Genomics 82:343-354(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Cloning of a cDNA encoding a human protein which binds a sequence in the c-myc gene similar to the interferon-stimulated response element."Gene 145:267-272(1994) [PubMed] [Europe PMC] [Abstract]
  7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors."J. Cell Biol. 191:367-381(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]