≡

Cofactor Of BRCA1 (COBRA1)

[Edit]

NELF-B; NELFB; Negative Elongation Factor Complex Member B

Cofactor Of BRCA1 (COBRA1)
CCC N311
HGNC 24324
MGI 1931035
PubMed 9171110
RGD 1307832
UniProt Q8WX92
Wiki COBRA1
NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2), either NELFC or NELFD (TH1L), and NELFE (RDBP). NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1) and SPT5 (SUPT5H), to cause transcriptional pausing of RNA polymerase II.BRCA1 induced large-scale chromatin decondensation in Chinese hamster ovary cells. COBRA1 bound one of the chromatin-unfolding domains of BRCA1, and by itself COBRA1 induced large-scale chromatin decondensation.NELFB and NELFE interacted directly and that NELFD interacted directly with NELFA and NELFB, consistent with a model in which NELFB and NELFD (or NELFC) bring NELFA and NELFE together via 3 protein-protein interactions. All 4 NELF subunits were required for NELF function.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cofactor Of BRCA1 (COBRA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cofactor Of BRCA1 (COBRA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cofactor Of BRCA1 (COBRA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cofactor Of BRCA1 (COBRA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cofactor Of BRCA1 (COBRA1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cofactor Of BRCA1 (COBRA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cofactor Of BRCA1 (COBRA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cofactor Of BRCA1 (COBRA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cofactor Of BRCA1 (COBRA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cofactor Of BRCA1 (COBRA1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cofactor Of BRCA1 (COBRA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cofactor Of BRCA1 (COBRA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cofactor Of BRCA1 (COBRA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cofactor Of BRCA1 (COBRA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cofactor Of BRCA1 (COBRA1) ELISA Kit Customized Service Offer
  1. "BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations."J. Cell Biol. 155:911-921(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex."Mol. Cell. Biol. 23:1863-1873(2003) [PubMed] [Europe PMC] [Abstract]
  8. "NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation."Cell 97:41-51(1999) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Characterizing the novel protein p33MONOX."Mol. Cell. Biochem. 350:127-134(2011) [PubMed] [Europe PMC] [Abstract]
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]