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Testis Specific Y Encoded Like Protein 2 (TSPYL2)

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TSPX; NP79; CTCL; DENTT; CDA1; CINAP; Cell division autoantigen 1; Cutaneous T-cell lymphoma-associated antigen se20-4; Differentially-expressed nucleolar TGF-beta1 target

Testis Specific Y Encoded Like Protein 2 (TSPYL2)
CCC N307
HGNC 24358
MGI 106244
PubMed 11318608
RGD 1563283
UniProt Q9H2G4
Wiki TSPYL2
CDA1 was phosphorylated by CDK4 , CDK2, and CDK1 (CDC2) in vitro, and mutation analysis showed that CDA1 was phosphorylated on ser20 and thr340 by CDK2 in HeLa cells. CDA1 levels were low in serum-starved HeLa cells and increased dramatically with serum stimulation. Expression of full-length CDA1, but not its N terminus, arrested HeLa cell growth, colony number, cell density, and bromodeoxyuridine uptake in a dose-dependent manner.
The ability of CDA1 to arrest cell growth was abolished by mutation of the 2 CDK consensus phosphorylation sites. CDA1 is a negative regulator of cell growth whose activity is regulated by its expression level and phosphorylation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Testis Specific Y Encoded Like Protein 2 (TSPYL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Testis Specific Y Encoded Like Protein 2 (TSPYL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Testis Specific Y Encoded Like Protein 2 (TSPYL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Testis Specific Y Encoded Like Protein 2 (TSPYL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Testis Specific Y Encoded Like Protein 2 (TSPYL2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Testis Specific Y Encoded Like Protein 2 (TSPYL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Testis Specific Y Encoded Like Protein 2 (TSPYL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Testis Specific Y Encoded Like Protein 2 (TSPYL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Testis Specific Y Encoded Like Protein 2 (TSPYL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Testis Specific Y Encoded Like Protein 2 (TSPYL2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Testis Specific Y Encoded Like Protein 2 (TSPYL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Testis Specific Y Encoded Like Protein 2 (TSPYL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Testis Specific Y Encoded Like Protein 2 (TSPYL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Testis Specific Y Encoded Like Protein 2 (TSPYL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Testis Specific Y Encoded Like Protein 2 (TSPYL2) ELISA Kit Customized Service Offer
  1. "SET-related cell division autoantigen-1 (CDA1) arrests cell growth."J. Biol. Chem. 276:33665-33674(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Serological detection of cutaneous T-cell lymphoma-associated antigens."Proc. Natl. Acad. Sci. U.S.A. 98:629-634(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of Differentially expressed nucleolar TGF-beta1 target (DENTT) in human lung cancer cells that is a new member of the TSPY/SET/NAP-1 superfamily."Genomics 73:179-193(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Selection system for genes encoding nuclear-targeted proteins."Nat. Biotechnol. 16:1338-1342(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Isolation of differentially expressed genes in human heart tissues."Biochim. Biophys. Acta 1588:241-246(2002) [PubMed] [Europe PMC] [Abstract]
  9. "TSPY, the candidate gonadoblastoma gene on the human Y chromosome, has a widely expressed homologue on the X -- implications for Y chromosome evolution."Chromosome Res. 12:345-356(2004) [PubMed] [Europe PMC] [Abstract]
  10. "A constitutively active arylhydrocarbon receptor induces growth inhibition of jurkat T cells through changes in the expression of genes related to apoptosis and cell cycle arrest."J. Biol. Chem. 279:25204-25210(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Differentially expressed nucleolar TGF-beta1 target (DENTT) shows tissue-specific nuclear and cytoplasmic localization and increases TGF-beta1-responsive transcription in primates."Biochim. Biophys. Acta 1728:163-180(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Antiproliferative autoantigen CDA1 transcriptionally up-regulates p21(Waf1/Cip1) by activating p53 and MEK/ERK1/2 MAPK pathways."J. Biol. Chem. 282:11722-11731(2007) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]