≡

Diabetes Related Ankyrin Repeat Protein (DARP)

[Edit]

ANKRD23; MARP3; Ankyrin Repeat Domain 23; Muscle ankyrin repeat protein 3

Diabetes Related Ankyrin Repeat Protein (DARP)
CCC N296
HGNC 24470
MGI 1925571
PubMed 24736439
RGD 1310398
UniProt Q86SG2
ANKRD23 belongs to the conserved muscle ankyrin repeat protein (MARP) family. Expression of MARPs is induced in response to physiologic stress, injury, and hypertrophy .
Darp was upregulated in the heart of the KKA(y) mouse, a type-2 diabetes and insulin resistance model. Darp expression was also altered in the insulin-resistant Zucker rat. Expression of mouse Darp in Chinese hamster ovary cells resulted in significantly decreased palmitate uptake. Furthermore, Darp expression was altered by changes of energy supply induced by excess fatty acid treatment of skeletal myotubes in vitro and in fasting mice in vivo. The deduced 305-amino acid protein has an N-terminal nuclear localization signal and 4 C-terminal ankyrin repeats.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Diabetes Related Ankyrin Repeat Protein (DARP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Diabetes Related Ankyrin Repeat Protein (DARP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Diabetes Related Ankyrin Repeat Protein (DARP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Diabetes Related Ankyrin Repeat Protein (DARP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Diabetes Related Ankyrin Repeat Protein (DARP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Diabetes Related Ankyrin Repeat Protein (DARP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Diabetes Related Ankyrin Repeat Protein (DARP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Diabetes Related Ankyrin Repeat Protein (DARP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Diabetes Related Ankyrin Repeat Protein (DARP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Diabetes Related Ankyrin Repeat Protein (DARP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Diabetes Related Ankyrin Repeat Protein (DARP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Diabetes Related Ankyrin Repeat Protein (DARP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Diabetes Related Ankyrin Repeat Protein (DARP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Diabetes Related Ankyrin Repeat Protein (DARP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Diabetes Related Ankyrin Repeat Protein (DARP) ELISA Kit Customized Service Offer
  1. "Molecular identification and characterization of a novel nuclear protein whose expression is up-regulated in insulin-resistant animals."J. Biol. Chem. 278:3514-3520(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules."J. Mol. Biol. 333:951-964(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]