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Dpy-30 Homolog (DPY30)

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Saf19; Dpy-30L; Dpy-30-like protein

Dpy-30 Homolog (DPY30)
CCC N287
HGNC 24590
MGI 1913560
RGD 708575
UniProt Q9C005
DPY30 is a component of a Set1-like multiprotein histone methyltransferase complex.DPY30 may form a stable oligomer. CD spectroscopy of the purified protein showed that DPY30 contains an alpha-helical structure.
DPY30 is part of a larger complex of PTIP-associated proteins including ASH2L, RBBP5, WDR5, NCOA6 , MLL3 , MLL4, and PA1 (C16ORF53). The protein complex is a Set1-like histone methyltransferase complex that displays histone H3 lysine-4 (H3K4) methyltransferase activity.DPY30 is a common subunit of all human Set1-like histone methyltransferase complexes and directly interacts with ASH2L but not with RBBP5 or WDR4.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dpy-30 Homolog (DPY30) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dpy-30 Homolog (DPY30) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dpy-30 Homolog (DPY30) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dpy-30 Homolog (DPY30) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dpy-30 Homolog (DPY30) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dpy-30 Homolog (DPY30) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dpy-30 Homolog (DPY30) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dpy-30 Homolog (DPY30) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dpy-30 Homolog (DPY30) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dpy-30 Homolog (DPY30) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dpy-30 Homolog (DPY30) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dpy-30 Homolog (DPY30) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dpy-30 Homolog (DPY30) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dpy-30 Homolog (DPY30) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dpy-30 Homolog (DPY30) ELISA Kit Customized Service Offer
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  2. "Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus."Mol. Cell 13:587-597(2004) [PubMed] [Europe PMC] [Abstract]
  3. "PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex."J. Biol. Chem. 282:20395-20406(2007) [PubMed] [Europe PMC] [Abstract]
  4. "Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS."Mol. Cell. Biol. 28:7337-7344(2008) [PubMed] [Europe PMC] [Abstract]
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  6. "On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex."J. Biol. Chem. 284:24242-24256(2009) [PubMed] [Europe PMC] [Abstract]
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  8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Role for Dpy-30 in ES cell-fate specification by regulation of H3K4 methylation within bivalent domains."Cell 144:513-525(2011) [PubMed] [Europe PMC] [Abstract]
  11. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  13. "Crystal structure of the C-terminal domain of human DPY-30-like protein: A component of the histone methyltransferase complex."J. Mol. Biol. 390:530-537(2009) [PubMed] [Europe PMC] [Abstract]