Enolase Phosphatase 1 (ENOPH1)

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MASA; E1; Enolase Phosphatase E1; Acireductone Synthase; 2,3-diketo-5-methylthio-1-phosphopentane phosphatase

Enolase Phosphatase 1 (ENOPH1)
ENOPH1 (enolase-phosphatase 1), also known as E1, MASA or MST145, is a member of the MasA family of the HAD (halo-acid dehalogenase)-like hydrolase superfamily. Existing as a monomer and binding magnesium as a cofactor, ENOPH1 is a bifunctional enzyme, exhibiting both phosphatase and atypical enolase activities. ENOPH1 plays an important role in the ubiquitous methionine salvage pathway, a biochemical pathway found in all organisms that regulates methionine levels in the cell (also known as the Yang cycle in plants). More specifically, ENOPH1 catalyzes the continuous enolization and dephosphorylation of 2,3-diketo-5-methylthio-1-phosphopentane to yield the aci-reductone metabolite 1,2-dihydroxy-3-keto-5-methylthiopentene. Due to alternative splicing events, two isoforms exist for ENOPH1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Enolase Phosphatase 1 (ENOPH1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Enolase Phosphatase 1 (ENOPH1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Enolase Phosphatase 1 (ENOPH1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Enolase Phosphatase 1 (ENOPH1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Enolase Phosphatase 1 (ENOPH1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Enolase Phosphatase 1 (ENOPH1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Enolase Phosphatase 1 (ENOPH1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Enolase Phosphatase 1 (ENOPH1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Enolase Phosphatase 1 (ENOPH1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Enolase Phosphatase 1 (ENOPH1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Enolase Phosphatase 1 (ENOPH1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Enolase Phosphatase 1 (ENOPH1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Enolase Phosphatase 1 (ENOPH1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Enolase Phosphatase 1 (ENOPH1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Enolase Phosphatase 1 (ENOPH1) ELISA Kit Customized Service Offer
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  5. "Crystal structure of human E1 enzyme and its complex with a substrate analog reveals the mechanism of its phosphatase/enolase activity."J. Mol. Biol. 348:917-926(2005) [PubMed] [Europe PMC] [Abstract]