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Transcription Factor Dp3 (TFDP3)

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CT30; DP4; HCA661; E2F-Like Protein; Cancer/Testis Antigen 30; Hepatocellular carcinoma-associated antigen 661

Transcription Factor Dp3 (TFDP3)
CCC N284
HGNC 24603
PubMed 24406621
UniProt Q5H9I0
TFDP3 encodes a member of the DP family of transcription factors. These factors heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. This protein functions as a negative regulator and inhibits the DNA binding and transcriptional activities of E2F factors.
The deduced 405-amino acid protein has a bipartite nuclear localization signal, a central DNA-binding and dimerization domain, and an RRTYC motif predicted to interact with E2F. DP4 shares over 90% identity with DP1 (TFDP1). Western blot analysis detected DP4 at an apparent molecular mass of about 45 kD, and immunostaining of transfected human osteosarcoma cell line showed the protein was expressed in the nucleus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transcription Factor Dp3 (TFDP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transcription Factor Dp3 (TFDP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transcription Factor Dp3 (TFDP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transcription Factor Dp3 (TFDP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcription Factor Dp3 (TFDP3) ELISA Kit Customized Service Offer
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  2. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  3. "A functionally distinct member of the DP family of E2F subunits."Oncogene 25:3212-3218(2006) [PubMed] [Europe PMC] [Abstract]
  4. "Human TFDP3, a novel DP protein, inhibits DNA binding and transactivation by E2F."J. Biol. Chem. 282:454-466(2007) [PubMed] [Europe PMC] [Abstract]
  5. "E2F-1 regulation by an unusual DNA damage-responsive DP partner subunit."Cell Death Differ. 18:122-132(2011) [PubMed] [Europe PMC] [Abstract]