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RAB11 Family Interacting Protein 5 (RAB11FIP5)

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GAF1;RIP11; pp75; Gamma-SNAP-associated factor 1; Phosphoprotein pp75; Rab11-interacting protein Rip11

RAB11 Family Interacting Protein 5 (RAB11FIP5)
CCC N249
HGNC 24845
MGI 1098586
PubMed 10048485
UniProt Q9BXF6
Wiki RAB11FIP5
RIP11 is important for protein trafficking from AREs to the apical plasma membrane. RIP11 is recruited to AREs by binding to RAB11, as well as through a Mg(2+)-dependent interaction of its C2 domain with neutral phospholipids. The association of RIP11 with membranes is regulated by a phosphorylation and dephosphorylation cycle.
Northern blot analysis detected 2 major RIP11 transcripts of 4.4 and 6 kb. Both transcripts were enriched in kidney, while other tissues expressed reduced levels of RIP11. Antibodies recognized a protein doublet of 72 kD. RIP11 was found to be enriched in polarized epithelial cells where, like Rab11, it localized to subapical recycling endosomes (AREs) and the apical plasma membrane.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAB11 Family Interacting Protein 5 (RAB11FIP5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAB11 Family Interacting Protein 5 (RAB11FIP5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAB11 Family Interacting Protein 5 (RAB11FIP5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAB11 Family Interacting Protein 5 (RAB11FIP5) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAB11 Family Interacting Protein 5 (RAB11FIP5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAB11 Family Interacting Protein 5 (RAB11FIP5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAB11 Family Interacting Protein 5 (RAB11FIP5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAB11 Family Interacting Protein 5 (RAB11FIP5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAB11 Family Interacting Protein 5 (RAB11FIP5) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAB11 Family Interacting Protein 5 (RAB11FIP5) ELISA Kit Customized Service Offer
  1. "A Rab11/Rip11 protein complex regulates apical membrane trafficking via recycling endosomes."Mol. Cell 6:1437-1448(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Defining a novel 75-kDa phosphoprotein associated with SS-A/Ro and identification of distinct human autoantibodies."J. Clin. Invest. 104:1265-1275(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Gaf-1, a gamma-SNAP-binding protein associated with the mitochondria."J. Biol. Chem. 276:13127-13135(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells."Biochem. Biophys. Res. Commun. 299:770-779(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Rab11b and its effector Rip11 regulate the acidosis-induced traffic of V-ATPase in salivary ducts."J. Cell. Physiol. 226:638-651(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]