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YEATS Domain Containing Protein 4 (YEATS4)

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NuBI-1; GAS41; YAF9; Glioma-amplified sequence 41; NuMA-binding protein 1

YEATS Domain Containing Protein 4 (YEATS4)
CCC N245
HGNC 24859
MGI 1927224
PubMed 22350108
RGD 1305741
UniProt O95619
GAS41 associated with TIP60 complex core subunits and with H2AZ (H2AFZ), a component of the SWI2/SNF2 (SMARCA2)-related CBP (CREBBP) activator protein (SRCAP) complex, confirming that GAS41 is a genuine subunit of the TIP60 and SRCAP complexes. Either knockdown of GAS41 expression with small interfering RNA or specific interruptions of the C-terminal coiled-coil motif of the GAS41 protein activated the p53 (TP53) tumor suppressor pathway. Activation of the p53 pathway did not result from changes in TIP60 complex assembly or TIP60 coactivator functions for p53. GAS41 was prebound to the promoters of 2 p53 tumor suppressor pathway genes, p21 (CDKN1A) and p14(ARF) (CDKN2A), in normal unstressed cells, but GAS41 dissociated from both promoters in response to p53-activating stress signals.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant YEATS Domain Containing Protein 4 (YEATS4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to YEATS Domain Containing Protein 4 (YEATS4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to YEATS Domain Containing Protein 4 (YEATS4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for YEATS Domain Containing Protein 4 (YEATS4) CLIA Kit Customized Service Offer
n/a ELISA Kit for YEATS Domain Containing Protein 4 (YEATS4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant YEATS Domain Containing Protein 4 (YEATS4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to YEATS Domain Containing Protein 4 (YEATS4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to YEATS Domain Containing Protein 4 (YEATS4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for YEATS Domain Containing Protein 4 (YEATS4) CLIA Kit Customized Service Offer
n/a ELISA Kit for YEATS Domain Containing Protein 4 (YEATS4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant YEATS Domain Containing Protein 4 (YEATS4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to YEATS Domain Containing Protein 4 (YEATS4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to YEATS Domain Containing Protein 4 (YEATS4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for YEATS Domain Containing Protein 4 (YEATS4) CLIA Kit Customized Service Offer
n/a ELISA Kit for YEATS Domain Containing Protein 4 (YEATS4) ELISA Kit Customized Service Offer
  1. "Cloning of a novel transcription factor-like gene amplified in human glioma including astrocytoma grade I."Hum. Mol. Genet. 6:1817-1822(1997) [PubMed] [Europe PMC] [Abstract]
  2. "GAS41, a highly conserved protein in eukaryotic nuclei, binds to NuMA."J. Biol. Chem. 275:31979-31985(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex."J. Biol. Chem. 278:42733-42736(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells."Biochem. J. 363:195-200(2002) [PubMed] [Europe PMC] [Abstract]
  7. "The MLL fusion partner AF10 binds GAS41, a protein that interacts with the human SWI/SNF complex."Blood 99:275-281(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Molecular cloning, genomic structure and interactions of the putative breast tumor suppressor TACC2."Genomics 81:192-201(2003) [PubMed] [Europe PMC] [Abstract]
  9. "The highly conserved and multifunctional NuA4 HAT complex."Curr. Opin. Genet. Dev. 14:147-154(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans."Mol. Cell. Biol. 24:1884-1896(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]