≡

Growth Regulation By Estrogen In Breast Cancer 1 (GREB1)

[Edit]

Gene regulated in breast cancer 1 protein

Growth Regulation By Estrogen In Breast Cancer 1 (GREB1)
CCC N242
HGNC 24885
MGI 2149712
PubMed 11103799
UniProt Q4ZG55
GREB1 is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.The deduced GREB1a, GREB1b, and GREB1c isoforms contain 1,949, 457, and 409 amino acids, respectively, and share a large central region and contain diverging 3-prime ends. GREB1b shares amino acids 1-449 with GREB1a, while GREB1c and GREB1a share identical amino acids 1-386. RT-PCR analysis detected GREB1 expression in ER (ESR1)-positive breast tumors with 3.5-fold higher expression in ER-positive compared with ER-negative breast tumors.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Growth Regulation By Estrogen In Breast Cancer 1 (GREB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Growth Regulation By Estrogen In Breast Cancer 1 (GREB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Growth Regulation By Estrogen In Breast Cancer 1 (GREB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Growth Regulation By Estrogen In Breast Cancer 1 (GREB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Growth Regulation By Estrogen In Breast Cancer 1 (GREB1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Growth Regulation By Estrogen In Breast Cancer 1 (GREB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Growth Regulation By Estrogen In Breast Cancer 1 (GREB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Growth Regulation By Estrogen In Breast Cancer 1 (GREB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Growth Regulation By Estrogen In Breast Cancer 1 (GREB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Growth Regulation By Estrogen In Breast Cancer 1 (GREB1) ELISA Kit Customized Service Offer
  1. "PDZK1 and GREB1 are estrogen-regulated genes expressed in hormone-responsive breast cancer."Cancer Res. 60:6367-6375(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Discovery of estrogen receptor alpha target genes and response elements in breast tumor cells."Genome Biol. 5:R66.1-R66.18(2004) [PubMed] [Europe PMC] [Abstract]
  6. "GREB 1 is a critical regulator of hormone dependent breast cancer growth."Breast Cancer Res. Treat. 92:141-149(2005) [PubMed] [Europe PMC] [Abstract]
  7. "GREB1 is a novel androgen-regulated gene required for prostate cancer growth."Prostate 66:886-894(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Regulation of GREB1 transcription by estrogen receptor alpha through a multipartite enhancer spread over 20 kb of upstream flanking sequences."J. Biol. Chem. 282:17335-17339(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Long-range activation of GREB1 by estrogen receptor via three distal consensus estrogen-responsive elements in breast cancer cells."Mol. Endocrinol. 21:2651-2662(2007) [PubMed] [Europe PMC] [Abstract]