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New Component Of The BRCA1 A Complex 1 (NBA1)

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BABAM1; HSPC142; MERIT40; C19orf62; Mediator Of Rap80 Interactions And Targeting 40 kD; BRISC and BRCA1-A complex member 1

New Component Of The BRCA1 A Complex 1 (NBA1)
CCC N228
HGNC 25008
MGI 1915501
RGD 1359516
UniProt Q9NWV8
MERIT40 was part of a BRCA1-associated protein complex containing BRE, BRCC36 (BRCC3), CCDC98 , and RAP80 (UIMC1).The MERIT40-BRE interaction also stabilized the entire protein complex, which was required for efficient BRCA1 foci formation and function at sites of DNA damage.
NBA1 was part of a BRCA1-associated complex in human cell lines and was required for BRCA1 focus formation. Knockdown of NBA1 via short hairpin RNA led to increased sensitivity of cells to DNA damage caused by IR, ultraviolet radiation, and chemical DNA-damaging agents. NBA1-depleted human osteosarcoma cells were unable to arrest efficiently in G2 in response to IR.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant New Component Of The BRCA1 A Complex 1 (NBA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to New Component Of The BRCA1 A Complex 1 (NBA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to New Component Of The BRCA1 A Complex 1 (NBA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for New Component Of The BRCA1 A Complex 1 (NBA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for New Component Of The BRCA1 A Complex 1 (NBA1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant New Component Of The BRCA1 A Complex 1 (NBA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to New Component Of The BRCA1 A Complex 1 (NBA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to New Component Of The BRCA1 A Complex 1 (NBA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for New Component Of The BRCA1 A Complex 1 (NBA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for New Component Of The BRCA1 A Complex 1 (NBA1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant New Component Of The BRCA1 A Complex 1 (NBA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to New Component Of The BRCA1 A Complex 1 (NBA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to New Component Of The BRCA1 A Complex 1 (NBA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for New Component Of The BRCA1 A Complex 1 (NBA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for New Component Of The BRCA1 A Complex 1 (NBA1) ELISA Kit Customized Service Offer
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