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Spindle And Centriole Protein (SPICE)

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SPICE1; CCDC52; Spindle And Centriole Associated Protein 1; Coiled-Coil Domain Containing 52

Spindle And Centriole Protein (SPICE)
CCC N214
HGNC 25083
MGI 1196252
PubMed 23810536
RGD 1310729
UniProt Q8N0Z3
In animal cells, the two poles of the mitotic spindle are organized by centrosomes, microtubule-organizing structures composed of a pair of centrioles surrounded by the so-called pericentriolar material. SPICE, a protein that localizes to spindle microtubules in mitosis and to centrioles throughout the cell cycle. RNAi-mediated depletion of SPICE in human cells impairs centriole duplication and causes severe mitotic defects.
SPICE depletion compromises spindle architecture, spindle pole integrity and chromosome congression, even in cells in which centriole duplication has occurred. SPICE is an important dual-function regulator required for centriole duplication and for proper bipolar spindle formation and chromosome congression in mitosis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Spindle And Centriole Protein (SPICE) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Spindle And Centriole Protein (SPICE) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Spindle And Centriole Protein (SPICE) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Spindle And Centriole Protein (SPICE) CLIA Kit Customized Service Offer
n/a ELISA Kit for Spindle And Centriole Protein (SPICE) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Spindle And Centriole Protein (SPICE) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Spindle And Centriole Protein (SPICE) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Spindle And Centriole Protein (SPICE) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Spindle And Centriole Protein (SPICE) CLIA Kit Customized Service Offer
n/a ELISA Kit for Spindle And Centriole Protein (SPICE) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Spindle And Centriole Protein (SPICE) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Spindle And Centriole Protein (SPICE) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Spindle And Centriole Protein (SPICE) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Spindle And Centriole Protein (SPICE) CLIA Kit Customized Service Offer
n/a ELISA Kit for Spindle And Centriole Protein (SPICE) ELISA Kit Customized Service Offer
  1. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  4. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  7. "SPICE -- a previously uncharacterized protein required for centriole duplication and mitotic chromosome congression."J. Cell Sci. 123:3039-3046(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]